{"id":8094,"date":"2021-12-16T12:17:39","date_gmt":"2021-12-16T17:17:39","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/ziconotide-acetate-cas-107452-89-1-behandling-for-postherpetisk-neuralgi-och-cancersmarta\/"},"modified":"2021-12-16T12:17:39","modified_gmt":"2021-12-16T17:17:39","slug":"ziconotide-acetate-cas-107452-89-1-behandling-for-postherpetisk-neuralgi-och-cancersmarta","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/sv\/product\/ziconotide-acetate-cas-107452-89-1-behandling-for-postherpetisk-neuralgi-och-cancersmarta\/","title":{"rendered":"Ziconotide Acetate CAS 107452-89-1 Behandling f\u00f6r postherpetisk neuralgi och cancersm\u00e4rta"},"content":{"rendered":"

Ziconotide Acetate CAS 107452-89-1 Behandling f\u00f6r postherpetisk neuralgi och cancersm\u00e4rta<\/strong><\/h2>\n

Produktnamn: Ziconotide acetate
\nSynonymer: OMEGA-CONOTOXIN MVIIA;OMEGA-CGTX MVII A;ZICONOTIDE ACETATE;snx111;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG -LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS -SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2 (DISULFIDBRO: 1-16, 8-20 OCH 15 -25);CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY- LYS-CYS-NH2;CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (DISULFIDBRO: 1-16,8-20, OCH 15-25)
\nCAS: 107452-89-1
\nMF: C102H172N36O39W:36O39W:36O39W:36O39W:3 >EINECS:
\nProduktkategorier: Peptid
\nMol Fil: 107452-89-1.mol<\/p>\n

Ziconotid (Prialt) \u00e4r en 25 aminosyror, tre disulfidbunden peptidtoxinf\u00f6rening som kommer fr\u00e5n s\u00f6dern Stillahavssnigel Conusmagus. Det \u00e4r det f\u00f6rsta nya neuroterapeutiska medlet – N-typ kalciumkanalblockerare (NCCB). Det verkar selektivt p\u00e5 N-typ elektrok\u00e4nsliga Chemicalbook kalciumkanaler i dendritiska och axonala terminala grenarna, och h\u00e4mmar d\u00e4rigenom initiala skadestimulans afferenter. Det \u00e4r indicerat f\u00f6r patienter med sv\u00e5r kronisk sm\u00e4rta som kr\u00e4ver intratekal behandling och som \u00e4r intoleranta mot eller har d\u00e5lig effekt av andra sm\u00e4rtstillande behandlingar (t.ex. applicering av systemiska sm\u00e4rtstillande medel eller intratekal morfin). Intratekal ziconotid kan anv\u00e4ndas f\u00f6r att behandla postherpetisk neuralgi, fantomsm\u00e4rta i extremiteterna, HIV-relaterad neuropatisk sm\u00e4rta, refrakt\u00e4r cancersm\u00e4rta och postkirurgisk sm\u00e4rta.<\/p>\n

Ziconotide Acetate CAS 107452-89-1 Kemiska egenskaper<\/strong>
\ndensitet 1,60\u00b10,1 g\/cm3(f\u00f6rutsp\u00e5dd)
\nlagringstemp. -20\u00b0C
\nInChIKey BPKIMPVREBSLAJ-QTBYCLKRSA-N<\/p>\n

Anv\u00e4ndningar av Ziconotide Acetate CAS 107452-89-1<\/strong>
\nLigand f\u00f6r bindningsstudier av sp\u00e4nningsk\u00e4nsliga kalciumkanaler.<\/p>\n

Ziconotid ( SNX-111; Prialt), \u00e4ven kallad intratekal ziconotid (ITZ) p\u00e5 grund av dess administreringsv\u00e4g, \u00e4r ett atypiskt sm\u00e4rtstillande medel f\u00f6r att lindra sv\u00e5r och kronisk sm\u00e4rta. H\u00e4rledd fr\u00e5n Conus magus, en konsnigel, \u00e4r det den syntetiska formen av en \u03c9-conotoxinpeptid.[1] Den \u00e4r 1 000 g\u00e5nger s\u00e5 kraftfull som morfin.<\/p>\n

Denna produkt \u00e4r l\u00e4mplig f\u00f6r patienter med sv\u00e5r kronisk sm\u00e4rta som kr\u00e4ver intratekal behandling och som \u00e4r intoleranta eller har d\u00e5lig effekt p\u00e5 andra sm\u00e4rtstillande behandlingar (som applicering av systemiska sm\u00e4rtstillande medel eller intratekal injektion av morfin, etc.).<\/p>\n

Funktion och till\u00e4mpning av Ziconotide Acetate CAS 107452-89-1<\/strong>
\n1. Sm\u00e4rtstillande effekt Ziconotide \u00e4r l\u00e4mplig f\u00f6r patienter med kronisk sm\u00e4rta som inte kan tolerera eller inte svarar p\u00e5 andra behandlingar, inklusive systemisk medicinering, adjuvansbehandling av intratekal injektion av morfin. Intratekal injektion av ziconotid har kliniskt och statistiskt signifikant analgetisk effekt hos patienter med cancer eller AIDS.<\/p>\n

2. Ryggm\u00e4rgsskydd Kortvarig ryggm\u00e4rgsischemi N\u00e4r ryggm\u00e4rgsneuroner \u00e4r skadade sker aktivering av en elektrok\u00e4nslig kalciumv\u00e4g av N-typ. Ziconotide kan ge neuroskydd och analgesi under aortakirurgi.<\/p>\n","protected":false},"excerpt":{"rendered":"

Produktnamn: Ziconotide acetate
\nCAS: 107452-89-1
\nMF: C102H172N36O32S7
\nMW: 2639.13
\nMol Fil: 107452-89-1.mol<\/p>\n","protected":false},"featured_media":2217,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[527],"product_tag":[1578],"class_list":{"0":"post-8094","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-andra-peptider","7":"product_tag-ziconotide-acetate-cas-107452-89-1-treat-for-postherpetic-neuralgia-and-cancer-pain-sv","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product\/8094","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/comments?post=8094"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/media\/2217"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/media?parent=8094"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product_brand?post=8094"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product_cat?post=8094"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product_tag?post=8094"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}