{"id":8300,"date":"2021-12-16T13:22:09","date_gmt":"2021-12-16T18:22:09","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/hogkvalitativ-peptid-somatostatinacetat-15-28-somatostatin-28-cas-38916-34-6\/"},"modified":"2021-12-16T13:22:09","modified_gmt":"2021-12-16T18:22:09","slug":"hogkvalitativ-peptid-somatostatinacetat-15-28-somatostatin-28-cas-38916-34-6","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/sv\/product\/hogkvalitativ-peptid-somatostatinacetat-15-28-somatostatin-28-cas-38916-34-6\/","title":{"rendered":"H\u00f6gkvalitativ peptid somatostatinacetat\/ 15-28-somatostatin-28 CAS 38916-34-6"},"content":{"rendered":"

H\u00f6gkvalitativ peptid somatostatinacetat\/ 15-28-somatostatin-28 CAS 38916-34-6<\/strong><\/h2>\n

Produktnamn: Somatostatin Acetate\/ 15-28-Somatostatin-28
\nSynonymer: Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH ;SoMatotropin Release-inhibering Factor, SRIF, SRIF-14;Cyklisk somatostatin;SoMatostatin Acetat;THOWTH HORMONE RELEASE H\u00e4mmande FAKTOR (M\u00c4NNISKA, F\u00c5R, PORCINE, RAT, MUS); MUS) 2ACOH 6H2O;H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH;H-ALA-GLY-CYS-LYS-ASN-PHE -PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH (KOPPLET TILL BSA)
\nCAS: 38916-34-6
\nMF: C76H104N18O19S2
\nMW: 1637.88
\nEINECS: 254-186-5
\nProduktkategorier: Aminosyraderivat;Aminosyror & derivat;Peptid;Aminosyror 13C, 2H, 15N;Intermedi\u00e4rer & finkemikalier;l\u00e4kemedel;peptider pharm
\nMol Fil: 38916-34 .mol<\/p>\n

Somatostatin \u00e4r en cyklisk 14-peptid som f\u00f6rst isolerades av Guillemin 1973 och \u00e4r f\u00f6rmodligen den mest grundligt unders\u00f6kta och viktigaste av de h\u00e4mmande faktorer som produceras av hypotan lamus. Den huvudsakliga aktiviteten f\u00f6r somatostatin, som \u00e4r av hypotalamiskt ursprung, \u00e4r h\u00e4mning av fris\u00e4ttningen av tillv\u00e4xthormon (GH) fr\u00e5n hypofysen. F\u00f6r mycket GH, som i hypofystum\u00f6rer, orsakar akromegali, en form av gigantism. \u00c5 andra sidan leder f\u00f6r lite GH till dv\u00e4rgv\u00e4xt. Somatostatin har ocks\u00e5 hittats i bukspottk\u00f6rteln och mag-tarmkanalen, d\u00e4r det h\u00e4mmar uts\u00f6ndringen av b\u00e5de insulin och glukagon fr\u00e5n bukspottk\u00f6rteln s\u00e5v\u00e4l som uts\u00f6ndringen av en m\u00e4ngd olika intestinala peptider (t.ex. gastrin, sekretin, pepsin och renin). Den korta halveringstiden f\u00f6r somatostatin, som \u00e4r mindre \u00e4n 3 minuter, har uteslutit dess anv\u00e4ndning som terapeutiskt medel. M\u00e5nga derivat av somatostatin har framst\u00e4llts f\u00f6r att \u00f6ka dess verkningsl\u00e4ngd och\/eller f\u00f6r att \u00f6ka dess verkningsselektivitet. Kulmen p\u00e5 dessa struktur-aktivitetsstudier var utvecklingen av oktreotidacetat.<\/p>\n

F\u00f6rutom hypotalamus, andra delar s\u00e5som hj\u00e4rnbarken, striatum, amygdala, hippocampus och ryggm\u00e4rg, sympatisk nerv, gastrointestinal, \u00f6-, njur-, sk\u00f6ldk\u00f6rtel- och bisk\u00f6ldk\u00f6rtlar \u00e4r brett spridda i somatostatin. I hj\u00e4rnan och mag-tarmkanalen renades 28 aminosyror av GHRIH28, som \u00e4r en ut\u00e5triktad f\u00f6rl\u00e4ngning av N-terminalen av GHRIH14. Effekten av somatostatin in vitro \u00e4r komplicerad, och den kan fungera som en s\u00e4ndare eller modulera i nervsystemet; somatostatin har en viss h\u00e4mmande effekt p\u00e5 gastrointestinal motilitet och uts\u00f6ndring av hormoner i matsm\u00e4ltningskanalen; det h\u00e4mmar \u00e4ven insulin och bukspottk\u00f6rtel Glukagon, renin, bisk\u00f6ldk\u00f6rtelhormon och kalcitonin.<\/p>\n

Somatostatin Acetate\/15-28-Somatostatin-28 CAS 38916-34-6 Kemiska egenskaper<\/strong>
\n15-28-Somatostatin-28 Kemiska egenskaper
\nKokpunkt 1970,9\u00b165,0 \u00b0C(F\u00f6rutsp\u00e5dd)
\ndensitet 1,43\u00b10,1 g\/cm3(F\u00f6rutsp\u00e5dd)
\nlagringstemp. \u221220\u00b0C
\nl\u00f6slighet H2O: 1 mg\/mL
\npka 2,94\u00b10,70(f\u00f6rutsp\u00e5dd)
\nform pulver
\nVattenl\u00f6slighet L\u00f6sligt i vatten (25,00\u00b0C 1,00 g\/L) , Metanol.
\nMerck 13,8788
\nBRN 6436064
\nInChIKey NHXLMOGPVYXJNR-ATOGVRKGSA-N<\/p>\n

Funktion och till\u00e4mpning av Somatostatin Acetate\/15-28-Somatostatin-28 CAS<\/strong> <& >
\n1 Det kan h\u00e4mma uts\u00f6ndringen av tillv\u00e4xthormon, sk\u00f6ldk\u00f6rtelstimulerande hormon, insulin, glukagon.<\/p>\n

2 Det kan h\u00e4mma magsyrauts\u00f6ndringen som stimuleras av testm\u00e5ltiden och 5-peptidgastrin, och kan h\u00e4mma fris\u00e4ttning av pepsin och gastrin.<\/p>\n

3 Det kan avsev\u00e4rt minska det viscerala blodfl\u00f6det, minska portaltrycket, minska blodfl\u00f6det och trycket i kollateral cirkulation, minska blodfl\u00f6det i levern.<\/p>\n

4 Det minskar sekretionen av bukspottk\u00f6rteln och uts\u00f6ndringen av tunntarmen och gallbl\u00e5san, minskar enzymaktiviteten och har en skyddande effekt p\u00e5 pankreasceller.<\/p>\n

5 Det kan p\u00e5verka upptaget och n\u00e4ringsfunktionen i mag-tarmkanalen.<\/p>\n","protected":false},"excerpt":{"rendered":"

Produktnamn: Somatostatin Acetate\/ 15-28-Somatostatin-28
\nCAS: 38916-34-6
\nMF: C76H104N18O19S2
\nMW: 1637.88
\nEINECS: 254-186-Mol
\nMW: 254-186-5 : 38916-34-6.mol<\/p>\n","protected":false},"featured_media":2133,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[527],"product_tag":[],"class_list":{"0":"post-8300","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-andra-peptider","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product\/8300","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/comments?post=8300"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/media\/2133"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/media?parent=8300"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product_brand?post=8300"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product_cat?post=8300"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product_tag?post=8300"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}