{"id":8387,"date":"2021-12-16T13:26:57","date_gmt":"2021-12-16T18:26:57","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/pramlintide-acetate-cas-196078-30-5-ar-ett-antidiabetiskt-medel-som-aven-kan-anvandas-i-tarmcancerforskning\/"},"modified":"2021-12-16T13:26:57","modified_gmt":"2021-12-16T18:26:57","slug":"pramlintide-acetate-cas-196078-30-5-ar-ett-antidiabetiskt-medel-som-aven-kan-anvandas-i-tarmcancerforskning","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/sv\/product\/pramlintide-acetate-cas-196078-30-5-ar-ett-antidiabetiskt-medel-som-aven-kan-anvandas-i-tarmcancerforskning\/","title":{"rendered":"Pramlintide Acetate CAS 196078-30-5 \u00e4r ett antidiabetiskt medel som \u00e4ven kan anv\u00e4ndas i tarmcancerforskning"},"content":{"rendered":"

Pramlintide Acetate CAS 196078-30-5 \u00e4r ett antidiabetiskt medel som \u00e4ven kan anv\u00e4ndas i tarmcancerforskning<\/strong><\/h2>\n

Produktnamn: Pramlintideacetat
\nSynonymer: AMYLIN (HUMAN), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ACETAT (SALT), HYDRATE;pramlintideacetat;pramlintideacetathydrat ;25-L-prolin-28-L-prolin-29-L-prolin-aMylin (huMan) Acetathydrat;AC-137 Acetathydrat, SyMlin Acetathydrat;Tripo-aMylinacetathydrat;Pramlintidacetat, Amylinr\u00e5tta;Pramlintide fandachem
\nCAS: 196078-30-5
\nMF: C173H273N51O56S2
\nMW: 4027.46
\nEINECS:
\nProduktkategorier: Aminosyror & Derivat;Baser & relaterade reagenser;Intermediate Analogs;Drugeterocycles; & Finkemikalier;Nukleotider;Peptid;L\u00e4kemedel
\nMol Fil: 196078-30-5.mol<\/p>\n

Pramlintidacetat \u00e4r en injicerbar human amylinanalog som har lanserats f\u00f6r behandling av b\u00e5de typ 1 och typ 2 diabetes, i samband med insulin. \u00c4ven om det ocks\u00e5 \u00e4r en peptid med 37 aminosyror, skiljer den sig fr\u00e5n sin moderf\u00f6reg\u00e5ngare genom att Ala-25, Ser-28 och Ser-29 ers\u00e4tts med proliner. Dessa modifieringar f\u00f6rb\u00e4ttrar inte bara l\u00f6sligheten av peptiden, de eliminerar ocks\u00e5 aggregationen som observeras med amylin, vilket resulterar i en stabil syntetisk analog med bibeh\u00e5llande av biologisk aktivitet som \u00e4r l\u00e4mplig f\u00f6r farmaceutisk anv\u00e4ndning. Som en indikation p\u00e5 styrka h\u00e4mmar Pramlintideacetat bindningen av radiojoderat r\u00e5ttamylin till r\u00e5ttk\u00e4rnans accumbensmembran med ett Ki-v\u00e4rde p\u00e5 23 pM. Dess verkningsmekanism efterliknar amylin; som ett neurohormon som samuts\u00f6ndras med insulin fr\u00e5n pankreasens \u03b2-celler som svar p\u00e5 m\u00e5ltider, \u00e4r det involverat i glukoshomeostas. B\u00e5da peptiderna s\u00e4nker postprandiala glukosniv\u00e5er genom att h\u00e4mma glukagon och genom att h\u00e5lla tillbaka den vagusmedierade hastigheten f\u00f6r magt\u00f6mning, och d\u00e4rigenom sakta ner kolhydratabsorptionen i tarmen. Dessutom har amylin, eller Pramlintide-acetat, den extra f\u00f6rdelen att inducera postprandial m\u00e4ttnad, vilket resulterar i viktminskning hos patienter med typ 2-diabetes. Eftersom Pramlintideacetat bromsar magt\u00f6mningen, \u00e4r det kontraindicerat hos patienter med gastropares och hos patienter som tar l\u00e4kemedel som f\u00f6r\u00e4ndrar gastrointestinal motilitet (antikolinerga medel, s\u00e5som atropin) eller saktar ner den intestinala absorptionen av n\u00e4rings\u00e4mnen (s\u00e5som \u03b1-glukosidash\u00e4mmare). Pramlintideacetat \u00e4r ocks\u00e5 kontraindicerat hos patienter med hypoglykemiska tendenser; p\u00e5 grund av samtidig administrering med insulin \u00e4r allvarlig insulininducerad hypoglykemi en risk. De vanligaste rapporterade biverkningarna inkluderar illam\u00e5ende, kr\u00e4kningar, anorexi, huvudv\u00e4rk, buksm\u00e4rtor, tr\u00f6tthet, yrsel, hosta och faryngit.<\/p>\n

Funktion och till\u00e4mpning av CAS 196078-30-5<\/strong> <\/p>\n

Pramlintide acetat \u00e4r en syntetisk analog av pankreas amyloidpolypeptid (Amylin, amylopectin) och \u00e4r det andra l\u00e4kemedlet som godk\u00e4nts f\u00f6r behandling av typ 1-diabetes efter insulin. I klinisk praxis anv\u00e4nds pramlintid som ett adjuvansl\u00e4kemedel f\u00f6r behandling av typ 1- och typ 2-diabetes, fr\u00e4mst f\u00f6r patienter med diabetes som inte har uppn\u00e5tt f\u00f6rv\u00e4ntade resultat med enbart insulin, och med kombinationen av insulin och sulfonylureider och metformin. Pramlintide kan anv\u00e4ndas i kombination med insulin, men det kan inte ers\u00e4tta insulin.<\/p>\n","protected":false},"excerpt":{"rendered":"

Produktnamn: Pramlintideacetat
\nCAS: 196078-30-5
\nMF: C173H273N51O56S2
\nMW: 4027.46
\nMol Fil: 196078-30-5.mol<\/p>\n","protected":false},"featured_media":2217,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[351],"product_tag":[1299],"class_list":{"0":"post-8387","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-diabetespeptid","7":"product_tag-pramlintide-acetate-cas-196078-30-5-is-an-antidiabetic-agent-that-can-also-be-used-in-bowel-cancer-research-sv","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product\/8387","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/comments?post=8387"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/media\/2217"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/media?parent=8387"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product_brand?post=8387"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product_cat?post=8387"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product_tag?post=8387"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}