{"id":8429,"date":"2021-12-16T13:29:08","date_gmt":"2021-12-16T18:29:08","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/hot-sale-farmaceutiska-peptider-pasireotid-cas-396091-73-9\/"},"modified":"2021-12-16T13:29:08","modified_gmt":"2021-12-16T18:29:08","slug":"hot-sale-farmaceutiska-peptider-pasireotid-cas-396091-73-9","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/sv\/product\/hot-sale-farmaceutiska-peptider-pasireotid-cas-396091-73-9\/","title":{"rendered":"Hot Sale Farmaceutiska Peptider Pasireotid CAS 396091-73-9"},"content":{"rendered":"

Hot Sale Farmaceutiska Peptider Pasireotid CAS 396091-73-9<\/strong><\/h2>\n

Produktnamn: PASIREOTIDE
\nSynonymer: PASIREOTIDE;Cyklo[(2S)-2-fenylglycyl-D-tryptofyl-L-lysyl-O-(fenylmetyl)-L-tyrosyl-L-fenylalanyl-(4R)- 4-[[[(2-aminoetyl)amino]karbonyl]oxi]-L-prolyl]; SOM 230; SOM 320; [(3S,6S,9S,12R,15S,18S,20R)-9-(4- aminobutyl)-3-bensyl-12-(lH-indol-3-ylmetyl)-2,5,8,11,14,17-hexaoxo-15-fenyl-6-[(4-fenylmetoxifenyl)metyl]-1, 4,7,10,13,16-hexazabicyklo[16.3.0]henikosan-20-yl]N-(2-aminoetyl)karbamat; SOM 230; SOM 320; CYKLO((4R)-4-(2-AMINOETYLCARBAMOYLOXY) -L-PROLYL-L-FENYLGLYCYL-D-TRYPTOPHYL-L-LYSYL-4-O-BENZYL-L-TYROSYL-L-FENYLALANYL-)
\nCAS: 396091-73-9
\nMF: C58H66N10O9<& >MW: 1047,23
\nEINECS:
\nProduktkategorier:
\nMol Fil: 396091-73-9.mol<\/p>\n

I april 2012 godk\u00e4nde Europeiska kommissionen pasireotid f\u00f6r behandling av Cushings sjukdom ( CD) hos vuxna patienter som inte har svarat p\u00e5 kirurgiskt ingrepp eller f\u00f6r vilka kirurgi inte \u00e4r valfritt. Pasireotid godk\u00e4ndes f\u00f6r samma indikation av amerikanska FDA i december 2012. Pasireotid (\u00e4ven k nun som SOM230) \u00e4r en cyklohexapeptid som fungerar som en somatostatinanalog f\u00f6r att h\u00e4mma fris\u00e4ttningen av ACTH. Somatostatiner \u00e4r cykliska peptider med 14 och 28 aminosyror som spelar en viktig roll f\u00f6r att reglera endokrina och exokrina fris\u00e4ttningar i m\u00e5nga v\u00e4vnader genom en h\u00e4mmande mekanism. Det finns fem k\u00e4nda undertyper av somatostatinreceptorer (SSTR). Naturliga somatostatiner binder med h\u00f6g affinitet till alla fem subtyperna, men deras terapeutiska anv\u00e4ndning begr\u00e4nsas av snabb nedbrytning i plasma. Pasireotid uppstod fr\u00e5n anstr\u00e4ngningar att identifiera ett somatostatinmimetikum med l\u00e5ngvariga h\u00e4mmande effekter. B\u00f6rjar med en 14-aminosyror somatostatinpeptid, avsl\u00f6jade en systematisk alaninskanning rester som var v\u00e4sentliga f\u00f6r bindning av receptorsubtyp, inklusive viktiga b-turnregioner och intilliggande rester. Att placera de viktigaste strukturella elementen som onaturliga aminosyror i en cyklohexapeptidryggrad gav pasireotid.<\/p>\n

PASIREOTIDE CAS 396091-73-9<\/strong>
\nKokpunkt 1351,4\u00b165,0 \u00b0C(F\u00f6rutsp\u00e5dd)
\n0,1 g densitet 1,36 \/cm3(Predicted)
\npka 11,86\u00b10,46(Predicted)
\nCAS DataBase Reference 396091-73-9<\/p>\n

Funktion och till\u00e4mpning av PASIREOTIDE CAS 396091-73-9<\/strong>
\nSom tillv\u00e4xth\u00e4mmare analog som binder till flera receptorer, pasireotid har visat sig vara effektivare \u00e4n tillv\u00e4xth\u00e4mmande analoger som oktreotid och lanreotid vid behandling av akromegali, karcinoida tum\u00f6rer och Cushings sjukdom, b\u00e5de i prekliniska pr\u00f6vningar som celltester och djurstudier, och i kliniska tester. Resultaten av fas II-studien och en fas III-studie p\u00e5 pasireotid har bekr\u00e4ftat att pasireotid \u00e4r en ny behandling f\u00f6r nya eller ih\u00e5llande akromegali och metastaserande karcinoidtum\u00f6rer, och kan vara f\u00f6rstahandsvalet av l\u00e4kemedelsbehandling f\u00f6r Cushings sjukdom.<\/p>\n","protected":false},"excerpt":{"rendered":"

Produktnamn: PASIREOTIDE
\nMF: C58H66N10O9
\nMW: 1047.23
\nEINECS:
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