{"id":8473,"date":"2021-12-16T13:31:32","date_gmt":"2021-12-16T18:31:32","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/atosiban-cas-90779-69-4-av-hog-kvalitet-ar-en-kombinerad-kontraktin-och-pressin-v1a-receptorantagonist\/"},"modified":"2021-12-16T13:31:32","modified_gmt":"2021-12-16T18:31:32","slug":"atosiban-cas-90779-69-4-av-hog-kvalitet-ar-en-kombinerad-kontraktin-och-pressin-v1a-receptorantagonist","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/sv\/product\/atosiban-cas-90779-69-4-av-hog-kvalitet-ar-en-kombinerad-kontraktin-och-pressin-v1a-receptorantagonist\/","title":{"rendered":"Atosiban CAS 90779-69-4 av h\u00f6g kvalitet \u00e4r en kombinerad kontraktin- och pressin-V1A-receptorantagonist"},"content":{"rendered":"

Atosiban CAS 90779-69-4 av h\u00f6g kvalitet \u00e4r en kombinerad kontraktin- och pressin-V1A-receptorantagonist<\/strong><\/h2>\n

Produktnamn: Atosiban
\nSynonymer: RW-22164;RW-22164;RWJ-22164;Atosiban Impurtiy;atosiban pris;1-deamino-2d-tyr-(oet)-4-thr-8-orn- oxytocin;oxytocin,1-(3-merkaptopropanosyra)-2-(o-etyl-d-tyrosin)-4-l-treonin-8-l;rwj22164;ATOSIBANACETAT
\nCAS: 90779-69-4<& >MF: C43H67N11O12S2
\nMW: 994.19
\nEINECS: 806-815-5
\nProduktkategorier: hormoner;Peptid
\nMol Fil: 90779-69-4.mol<\/p>\n

Atosiban var introducerades i Storbritannien som en injicerbar h\u00e4mmare av prematur f\u00f6rlossning, en viktig orsak till sp\u00e4dbarnssjuklighet och mortalitet. Denna peptidiska oxytocinanalog \u00e4r en antagonist till vasopressin V1a-receptorn och till oxytocinreceptorn som \u00e5terfinns i dramatiskt \u00f6kad koncentration i livmodermyometrium hos gravida kvinnor p\u00e5 kort sikt. Det h\u00e4mmade kompetitivt sammandragningar i det gravida marsvinets livmoder inducerade av oxytocin och vasopressin. I en multicenter, dubbelblind, placebokontrollerad studie orsakade behandling med atosiban graviditetsf\u00f6rl\u00e4ngning i upp till 7 dagar hos kvinnor med mer \u00e4n 28 veckors graviditet. I en j\u00e4mf\u00f6rande klinisk pr\u00f6vning visade atosiban en tokolytisk verkan (livmoderavslappnande medel) som var j\u00e4mf\u00f6rbar med ritodrin, men den f\u00f6rra tolererades betydligt b\u00e4ttre, s\u00e4rskilt med avseende p\u00e5 moderns kardiovaskul\u00e4ra biverkningar. Hos friska frivilliga minskade plasmaniv\u00e5erna av atosiban bi-exponentiellt med en initial och en terminal halveringstid p\u00e5 21 min respektive 1,7 timmar.<\/p>\n

Atosiban \u00e4r en kombinerad receptorantagonist av contractin och pressin V1A. Strukturen hos kontraktinreceptorn och pressin V1A-receptorn \u00e4r liknande. N\u00e4r den kontraktila hormonreceptorn \u00e4r blockerad, kan kontraktilt hormon fortfarande verka genom V1A-receptorn, s\u00e5 det \u00e4r n\u00f6dv\u00e4ndigt att blockera de tv\u00e5 ovanst\u00e5ende receptorverkansv\u00e4garna n\u00e4r samma kemikaliebok anv\u00e4nds, och en enda antagonism av en receptor kan effektivt h\u00e4mma livmoderkontraktion. Detta \u00e4r en av huvudorsakerna till att beta-agonister, kalciumkanalblockerare och prostaglandinsyntas-h\u00e4mmare inte effektivt h\u00e4mmar livmoderkontraktioner.<\/p>\n

Atosiban CAS 90779-69-4 Kemiska egenskaper<\/strong>
\nKokpunkt 1469,0\u00b165,0 \u00b0C (F\u00f6rutsp\u00e5dd)
\ndensitet 1,254\u00b10,06 g\/cm3(F\u00f6rutsp\u00e5dd)
\nlagringstemp. -20\u00b0C
\nl\u00f6slighet H2O: \u2264100 mg\/mL
\nform fast
\npka 12,81\u00b10,70(f\u00f6rutsp\u00e5dd)
\nCAS DataBase Reference 90779-69-4(CAS DataBase Reference)
\n< &> Funktion och till\u00e4mpning av Atosiban CAS 90779-69-4<\/strong>
\n1. F\u00f6r tidig f\u00f6rlossning
\n2. Atosiban \u00e4r ett oxytocinreceptorblockerande medel vid behandling av experimentell endometrios och visade sig uppvisa betydande terapeutisk effektivitet.<\/p>\n

Atosiban Anticancerforskning Antitum\u00f6reffekterna av den eteriska oljan av O. falcata testades i transplanterade murina H22 solida tum\u00f6rer in vivo . Tillv\u00e4xth\u00e4mningen i H22 solida tum\u00f6rer var m\u00e5ttlig (Yang et al. 2013).<\/p>\n","protected":false},"excerpt":{"rendered":"

Produktnamn: Atosiban
\nCAS: 90779-69-4
\nMF: C43H67N11O12S2
\nMW: 994.19
\nEINECS: 806-815-5
\nMol Fil: 90779-69-4.mol<\/p>\n","protected":false},"featured_media":2133,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[445,445,445,445],"product_tag":[1236],"class_list":{"0":"post-8473","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-urogenital-peptid","10":"product_tag-high-quality-atosiban-cas-90779-69-4-is-a-combined-contractin-and-pressin-v1a-receptor-antagonist-sv","11":"desktop-align-left","12":"tablet-align-left","13":"mobile-align-left","15":"first","16":"instock","17":"shipping-taxable","18":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product\/8473","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/comments?post=8473"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/media\/2133"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/media?parent=8473"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product_brand?post=8473"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product_cat?post=8473"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product_tag?post=8473"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}