{"id":8575,"date":"2021-12-17T01:47:31","date_gmt":"2021-12-17T06:47:31","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/nesiritide-bnp-32-human-cas-124584-08-3-natriuretisk-hjarnpeptid-for-hjartsvikt\/"},"modified":"2021-12-17T01:47:31","modified_gmt":"2021-12-17T06:47:31","slug":"nesiritide-bnp-32-human-cas-124584-08-3-natriuretisk-hjarnpeptid-for-hjartsvikt","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/sv\/product\/nesiritide-bnp-32-human-cas-124584-08-3-natriuretisk-hjarnpeptid-for-hjartsvikt\/","title":{"rendered":"Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3 Natriuretisk hj\u00e4rnpeptid f\u00f6r hj\u00e4rtsvikt"},"content":{"rendered":"

Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3 Natriuretisk hj\u00e4rnpeptid f\u00f6r hj\u00e4rtsvikt<\/strong><\/h2>\n

Produktnamn: Nesiritide \/ BNP-32 (HUMAN)
\nSynonymer: Nesiritide, Brain Natriuretic Peptide-32 human, BNP-32, >98%;BNP-32 (human) hydrochloride;Nesiritide [USAN:INN] ;SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH (DISULFIDBRO: 10-26);SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER -SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS;H-SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY -ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS-OH;H-SER-PRO-LYS -MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL -LEU-ARG-ARG-HIS-OH (DISULFIDBRO: 10-26); HJ\u00c4RNANATRIURETISK PEPTID (1-32), HUMAN
\nCAS: 124584-08-3
\nMF: C143H244N50O42S4
\nMW: 3464.04
\nEINECS: 1312995-182-4
\nProduktkategorier:
\nMol Fil: 124584-08-3.mol<\/p>\n

Nesiritide introducerades i USA som en ny intraven\u00f6s behandling f\u00f6r patienter med akut dekompenserad kongestiv hj\u00e4rtsvikt som har dyspn\u00e9 i vila eller med minimal aktivitet ity. Nesiritide \u00e4r den f\u00f6rsta humana rekombinanta formen av den potenta vasodilaterande natriuretiska peptiden av B-typ (\u00e4ven k\u00e4nd som hj\u00e4rnans natriuretisk peptid), en naturligt f\u00f6rekommande peptid med 32 aminosyror med en disulfidbunden ringstruktur p\u00e5 17 aminosyror. Nesiritid binder till den natriuretiska peptidreceptorn Atype p\u00e5 ytan av endotelceller och glatta muskelceller och stimulerar produktionen av den andra budb\u00e4raren cGMP som f\u00f6rmedlar huvudsakligen vaskul\u00e4r glattmuskelcellavslappning. Det underl\u00e4ttar ocks\u00e5 elimineringen av natrium och vatten genom njurarna och minskar uts\u00f6ndringen av vissa hormoner, s\u00e5som adrenalin, angiotensin II, aldosteron och endotelin, vilket framkallar skadliga l\u00e5ngsiktiga effekter inklusive blodk\u00e4rlsf\u00f6rtr\u00e4ngning och f\u00f6rh\u00f6jt blodtryck. I kliniska pr\u00f6vningar med hj\u00e4rtsviktspatienter minskade nesidtid dosberoende pulmon\u00e4rt kapill\u00e4rkiltryck, h\u00f6ger f\u00f6rmakstryck och systemiskt vaskul\u00e4rt motst\u00e5nd och \u00f6kade hj\u00e4rtindex utan att p\u00e5verka hj\u00e4rtfrekvensen. Den huvudsakliga biverkningen som observerades var dosberoende hypotoni. I en j\u00e4mf\u00f6rande fas III-studie visade sig nesiritid vara \u00f6verl\u00e4gsen iv. nitroglycerin i sina hemodynamiska effekter samt l\u00e4ttare att administrera och tolereras b\u00e4ttre. Nesiritid elimineras genom proteolytisk klyvning av enzymet neutralt endopeptidas NEP24.11 och genom bindning till den natriuretiska peptidreceptorn av C-typ f\u00f6ljt av endocytos och intracellul\u00e4r lysosomal hydrolys. Eftersom det har en kort halveringstid (18 min), administreras nesiritid som en 21 \u03bcg\/kg bolusinfusion f\u00f6ljt av en kontinuerlig underh\u00e5llsinfusion med 0,011 \u03bcg\/kg\/min, vanligtvis under 24-48 timmar.<\/p>\n

Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3 Kemiska egenskaper<\/strong>
\nBNP-32 (HUMAN) Kemiska egenskaper
\ndensitet 1,52\u00b10,1 g\/cm3(F\u00f6rutsp\u00e5dd)
\nRTECS EE1534000
\nlagringstemp. \u221220\u00b0C
\nform pulver
\nVattenl\u00f6slighet L\u00f6slig i vatten vid 1mg\/ml
\nCAS DataBase Reference 124584-08-3<\/p>\n

Funktion och till\u00e4mpning av Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3<\/strong>
\nBehandling av kronisk hj\u00e4rtsvikt (renin-angiotensinsystemantagonist).<\/p>\n","protected":false},"excerpt":{"rendered":"

Produktnamn: Nesiritide \/ BNP-32 (HUMAN)
\nCAS: 124584-08-3
\nMF: C143H244N50O42S4
\nMW: 3464.04
\nEINECS: 1312995-182-4
\nProduktkategorier:
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