{"id":7260,"date":"2021-12-16T07:20:04","date_gmt":"2021-12-16T12:20:04","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/anti-hiv-icin-enfuvirtid-enfuvirtide-asetat-cas-159519-65-0\/"},"modified":"2021-12-16T07:20:04","modified_gmt":"2021-12-16T12:20:04","slug":"anti-hiv-icin-enfuvirtid-enfuvirtide-asetat-cas-159519-65-0","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/tr\/product\/anti-hiv-icin-enfuvirtid-enfuvirtide-asetat-cas-159519-65-0\/","title":{"rendered":"Anti HIV \u0130\u00e7in Enfuvirtid \/ Enfuvirtide Asetat CAS 159519-65-0"},"content":{"rendered":"

Anti HIV \u0130\u00e7in Enfuvirtid \/ Enfuvirtide Asetat CAS 159519-65-0<\/strong><\/h2>\n

\u00dcr\u00fcn Ad\u0131: Enfuvirtide
\nS\u0131ra: Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys< &>-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
\nE\u015f Anlamlar\u0131: Enfuvirtide; T-2;Enfuvirtide Asetat (T-20);ENFUVIRTIDE(T-20) 98+%;Enfurvitide(T-20);Pentafusid;Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile -Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn -Trp-Phe-NH{2};Enfuvirtide;Aids059486
\nCAS: 159519-65-0
\nMF: C204H301N51O64
\nMW: 4491.92
\nEINECS: 641-385-0
\n\u00dcr\u00fcn Kategorileri : proteinler;Peptid
\nMol Dosya: 159519-65-0.mol<\/p>\n

Viral zarf glikoproteinine ba\u011flanabilen ve vir\u00fcs i\u00e7in gerekli konformasyonel de\u011fi\u015fiklikleri \u00f6nleyebilen, HIV f\u00fczyonunun sentetik bir peptit inhibit\u00f6r\u00fcd\u00fcr. h\u00fccre zar\u0131 ile kayna\u015farak HIV-1 replikasyonunu inhibe eder. Enfevir peptidi, gp41'in HR2 alan\u0131nda do\u011fal olarak olu\u015fan bir amino asit dizisinden t\u00fcretilir. Enfevir peptidi, HR2 alan\u0131n\u0131n aktivitesini sim\u00fcle ederek ve gp41'in HR1 alan\u0131na rekabet\u00e7i bir \u015fekilde ba\u011flanarak, HR1 ve HR2 aras\u0131ndaki etkile\u015fimi ve Gp41'in konfig\u00fcrasyonundaki de\u011fi\u015fiklikleri \u00f6nler, b\u00f6ylece vir\u00fcs\u00fcn konak\u00e7\u0131 h\u00fccrelerle kayna\u015fmas\u0131n\u0131 \u00f6nler.<\/p>\n

Enfuvirtide, viral ve h\u00fccresel membranlar\u0131n kayna\u015fmas\u0131n\u0131 engelleyerek HIV-1'in giri\u015fini engelleyen yeni bir HIV terap\u00f6tik s\u0131n\u0131f\u0131n\u0131n ilkidir. Viral zarf glikoproteininin ghe gp41 alt birimindeki ilk heptad tekrar\u0131na (HR1) ba\u011flan\u0131r ve h\u00fccre zarlar\u0131 ile f\u00fczyon i\u00e7in gerekli olan konformasyonel de\u011fi\u015fiklikleri \u00f6nler, b\u00f6ylece yeni bir mekanizmay\u0131 temsil eder. Laboratuarda ve birincil izolatlarda (HIV-1 clades A-G) 4 ila 280 nM (18-1260 ng\/mL) aras\u0131nda de\u011fi\u015fen bir IC50 ile bu ba\u011flanman\u0131n g\u00fc\u00e7l\u00fc bir inhibit\u00f6r\u00fcd\u00fcr, ancak HIV-2'ye kar\u015f\u0131 neredeyse hi\u00e7 aktivitesi yoktur. E\u015fsiz mekanizmas\u0131 nedeniyle NRTI, NNRTI ve PI'lere \u00e7apraz diren\u00e7 g\u00f6stermez. \u00c7\u00f6zelti ve kat\u0131 faz ad\u0131mlar\u0131n\u0131n bir kombinasyonu kullan\u0131larak kimyasal sentezle haz\u0131rlan\u0131r. Kat\u0131 faz a\u015famalar\u0131, dokuz ila on alt\u0131 amino asit aras\u0131nda de\u011fi\u015fen uzunluklarda peptitler \u00fcretmek i\u00e7in fmoc korumas\u0131n\u0131 ve aside duyarl\u0131 2-klorotritil klor\u00fcr re\u00e7inesini kullan\u0131r. <\/p>\n

Enfuvirtide\/ Enfuvirtide Asetat CAS 159519-65-0 Kimyasal \u00d6zellikler<\/strong>
\ndepolama s\u0131cakl\u0131\u011f\u0131. -20\u00b0C
\ntoz olu\u015fturur
\nrenk beyazdan kirli beyaza<\/p>\n

Enfuvirtid\/ Enfuvirtid Asetat Kullan\u0131mlar\u0131 CAS 159519-65-0<\/strong>
\n\u0130nsan i\u00e7in ters transkriptaz ila\u00e7lar\u0131 ile birlikte kullan\u0131l\u0131r. imm\u00fcn yetmezlik vir\u00fcs\u00fc (HIV) enfeksiyonu.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u00dcr\u00fcn Ad\u0131: Enfuvirtide
\nCAS: 159519-65-0
\nMF: C204H301N51O64
\nMW: 4491.92
\nEINECS: 641-385-0
\nMol Dosyas\u0131: 159519-65-0.mol<\/p>\n","protected":false},"featured_media":2135,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[529],"product_tag":[2498],"class_list":{"0":"post-7260","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-diger-peptitler","7":"product_tag-enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-for-anti-hiv-tr","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product\/7260","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/comments?post=7260"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/media\/2135"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/media?parent=7260"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product_brand?post=7260"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product_cat?post=7260"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product_tag?post=7260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}