{"id":8110,"date":"2021-12-16T12:18:42","date_gmt":"2021-12-16T17:18:42","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/ziconotide-asetat-cas-107452-89-1-postherpetik-nevralji-ve-kanser-agrisi-icin-tedavi\/"},"modified":"2021-12-16T12:18:42","modified_gmt":"2021-12-16T17:18:42","slug":"ziconotide-asetat-cas-107452-89-1-postherpetik-nevralji-ve-kanser-agrisi-icin-tedavi","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/tr\/product\/ziconotide-asetat-cas-107452-89-1-postherpetik-nevralji-ve-kanser-agrisi-icin-tedavi\/","title":{"rendered":"Ziconotide Asetat CAS 107452-89-1 Postherpetik nevralji ve kanser a\u011fr\u0131s\u0131 i\u00e7in tedavi"},"content":{"rendered":"

Ziconotide Asetat CAS 107452-89-1 Postherpetik nevralji ve kanser a\u011fr\u0131s\u0131 i\u00e7in tedavi<\/strong><\/h2>\n

\u00dcr\u00fcn Ad\u0131: Ziconotide asetat
\nE\u015f Anlaml\u0131lar: OMEGA-CONOTOXIN MVIIA;OMEGA-CGTX MVII A;ZICONOTIDE ACETATE;snx111;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG -LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS -SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2 (D\u0130S\u00dcLF\u0130T K\u00d6PR\u00dcS\u00dc: 1-16, 8-20 ve 15 -25);CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY- LYS-CYS-NH2;CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (D\u0130S\u00dcLF\u0130T K\u00d6PR\u00dcS\u00dc: 1-16,8-20, VE 15-25)
\nCAS: 107452-89-1
\nMF: C102H172N36O32S7
\nMW: 2639.13<& >EINECS:
\n\u00dcr\u00fcn Kategorileri: Peptit
\nMol Dosya: 107452-89-1.mol<\/p>\n

Zikonotid (Prialt), G\u00fcney'den t\u00fcretilen 25 amino asit, \u00fc\u00e7 dis\u00fclfid ba\u011fl\u0131 peptit toksin bile\u015fi\u011fidir. Pasifik deniz salyangozu Conusmagus. \u0130lk yeni n\u00f6roterap\u00f6tik ajand\u0131r – N-tipi kalsiyum kanal blokeri (NCCB). Dendritik ve aksonal terminal dallar\u0131nda N-tipi elektroduyarl\u0131 Chemicalbook kalsiyum kanallar\u0131 \u00fczerinde se\u00e7ici olarak etki eder, b\u00f6ylece ilk yaralanma uyaran afferentlerini inhibe eder. \u015eiddetli kronik a\u011fr\u0131s\u0131 olan, intratekal tedavi gerektiren ve di\u011fer analjezik tedavilere (\u00f6rn. \u0130ntratekal zikonotid, postherpetik nevralji, fantom uzuv a\u011fr\u0131s\u0131, HIV ile ili\u015fkili n\u00f6ropatik a\u011fr\u0131, diren\u00e7li kanser a\u011fr\u0131s\u0131 ve ameliyat sonras\u0131 a\u011fr\u0131y\u0131 tedavi etmek i\u00e7in kullan\u0131labilir.<\/p>\n

Zikonotid Asetat CAS 107452-89-1 Kimyasal \u00d6zellikler<\/strong>
\nyo\u011funluk 1,60\u00b10,1 g\/cm3(Tahmini)
\nsaklama s\u0131cakl\u0131\u011f\u0131. -20\u00b0C
\nInChIKey BPKIMPVREBSLAJ-QTBYCLKRSA-N<\/p>\n

Zikonotid Asetat CAS 107452-89-1<\/strong>
\nLigand voltaja duyarl\u0131 kalsiyum kanallar\u0131n\u0131n ba\u011flanma \u00e7al\u0131\u015fmalar\u0131 i\u00e7in.<\/p>\n

Zikonotid ( Uygulama yolu nedeniyle intratekal zikonotid (ITZ) olarak da adland\u0131r\u0131lan SNX-111; Prialt, \u015fiddetli ve kronik a\u011fr\u0131n\u0131n iyile\u015ftirilmesi i\u00e7in atipik bir analjezik ajand\u0131r. Bir koni salyangozu olan Conus magus'tan t\u00fcretilmi\u015ftir, bir \u03c9-konotoksin peptidinin sentetik formudur.[1] Morfinden 1000 kat daha g\u00fc\u00e7l\u00fcd\u00fcr.<\/p>\n

Bu \u00fcr\u00fcn, intratekal tedavi gerektiren \u015fiddetli kronik a\u011fr\u0131lar\u0131 olan ve di\u011fer analjezik tedavilere (sistemik analjezikler veya intratekal morfin enjeksiyonu, vb.).<\/p>\n

Zikonotid Asetat CAS 107452-89-1'in \u0130\u015flevi ve Uygulamas\u0131<\/strong>
\n1. Analjezik etkinlik Ziconotid, sistemik ila\u00e7 tedavisi, intratekal morfin enjeksiyonunun adjuvan tedavisi dahil olmak \u00fczere di\u011fer tedavileri tolere edemeyen veya bunlara yan\u0131t vermeyen kronik a\u011fr\u0131l\u0131 hastalar i\u00e7in uygundur. Zikonotidin intratekal enjeksiyonu, kanser veya AIDS'li hastalarda klinik ve istatistiksel olarak anlaml\u0131 analjezik etkinli\u011fe sahiptir.<\/p>\n

2. Omurilik korumas\u0131 K\u0131sa s\u00fcreli omurilik iskemisi Omurilik n\u00f6ronlar\u0131 hasar g\u00f6rd\u00fc\u011f\u00fcnde, N tipi elektrosensitif kalsiyum yolu aktivasyonu vard\u0131r. Zikonotid, aort cerrahisi s\u0131ras\u0131nda n\u00f6roproteksiyon ve analjezi sa\u011flayabilir.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u00dcr\u00fcn Ad\u0131: Zikonotid asetat
\nCAS: 107452-89-1
\nMF: C102H172N36O32S7
\nMW: 2639.13
\nMol Dosya: 107452-89-1.mol<\/p>\n","protected":false},"featured_media":2219,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[],"product_tag":[1587],"class_list":{"0":"post-8110","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_tag-ziconotide-acetate-cas-107452-89-1-treat-for-postherpetic-neuralgia-and-cancer-pain-tr","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product\/8110","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/comments?post=8110"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/media\/2219"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/media?parent=8110"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product_brand?post=8110"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product_cat?post=8110"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product_tag?post=8110"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}