{"id":8384,"date":"2021-12-16T13:26:56","date_gmt":"2021-12-16T18:26:56","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/pramlintide-asetat-cas-196078-30-5-bagirsak-kanseri-arastirmalarinda-da-kullanilabilen-bir-antidiyabetik-ajandir\/"},"modified":"2021-12-16T13:26:56","modified_gmt":"2021-12-16T18:26:56","slug":"pramlintide-asetat-cas-196078-30-5-bagirsak-kanseri-arastirmalarinda-da-kullanilabilen-bir-antidiyabetik-ajandir","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/tr\/product\/pramlintide-asetat-cas-196078-30-5-bagirsak-kanseri-arastirmalarinda-da-kullanilabilen-bir-antidiyabetik-ajandir\/","title":{"rendered":"Pramlintide Asetat CAS 196078-30-5, ba\u011f\u0131rsak kanseri ara\u015ft\u0131rmalar\u0131nda da kullan\u0131labilen bir antidiyabetik ajand\u0131r."},"content":{"rendered":"

Pramlintide Asetat CAS 196078-30-5, ba\u011f\u0131rsak kanseri ara\u015ft\u0131rmalar\u0131nda da kullan\u0131labilen bir antidiyabetik ajand\u0131r.<\/strong><\/h2>\n

\u00dcr\u00fcn Ad\u0131: Pramlintide asetat
\nE\u015f Anlamlar\u0131: AMYLIN (\u0130NSAN), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ASETAT (TUZ), H\u0130DRAT;pramlintid asetat;pramlintid asetat hidrat ;25-L-Prolin-28-L-prolin-29-L-prolin-aMylin (insan) Asetat Hidrat;AC-137 Asetat Hidrat, SyMlin Asetat Hidrat;Tripo-aMylin Asetat Hidrat;Pramlintid Asetat, Amilin S\u0131\u00e7an;Pramlintid asetat fandachem
\nCAS: 196078-30-5
\nMF: C173H273N51O56S2
\nMW: 4027.46
\nEINECS:
\n\u00dcr\u00fcn Kategorileri: Amino Asitler ve T\u00fcrevler;Bazlar ve \u0130lgili Reaktifler;\u0130la\u00e7 Analoglar\u0131;Heterosikller;Ara \u00fcr\u00fcnler & Fine Chemicals;Nucleotides;Peptide;Pharmaceuticals
\nMol Dosya: 196078-30-5.mol<\/p>\n

Pramlintide asetat, hem tip 1 hem de tip 2 tedavisi i\u00e7in piyasaya s\u00fcr\u00fclen enjekte edilebilir bir insan amilin analo\u011fudur. diyabet, ins\u00fclin ile birlikte. Ayn\u0131 zamanda 37 amino asitli bir peptit olmas\u0131na ra\u011fmen, Ala-25, Ser-28 ve Ser-29'un prolinlerle ikame edilmesiyle ana selefinden farkl\u0131d\u0131r. Bu modifikasyonlar sadece peptidin \u00e7\u00f6z\u00fcn\u00fcrl\u00fc\u011f\u00fcn\u00fc iyile\u015ftirmekle kalmaz, ayn\u0131 zamanda amilin ile g\u00f6zlemlenen agregasyonu da ortadan kald\u0131r\u0131r ve farmas\u00f6tik kullan\u0131m i\u00e7in uygun biyolojik aktivitenin muhafaza edildi\u011fi stabil bir sentetik analog ile sonu\u00e7lan\u0131r. Potansiyelin bir g\u00f6stergesi olarak, Pramlintide asetat radyoiyotlu s\u0131\u00e7an amilininin s\u0131\u00e7an \u00e7ekirde\u011fine ba\u011flanmas\u0131n\u0131 inhibe eder ve 23 pM Ki de\u011feri ile membranlar\u0131 biriktirir. Etki mekanizmas\u0131 amilin'i taklit eder; Yemeklere yan\u0131t olarak pankreas \u03b2 h\u00fccrelerinden ins\u00fclin ile birlikte salg\u0131lanan bir n\u00f6rohormon olarak glukoz homeostaz\u0131nda yer al\u0131r. Her iki peptit de glukagonu inhibe ederek ve vagus arac\u0131l\u0131 mide bo\u015falma h\u0131z\u0131n\u0131 s\u0131n\u0131rlayarak, b\u00f6ylece ba\u011f\u0131rsak karbonhidrat emilimini yava\u015flatarak tokluk glikoz seviyelerini d\u00fc\u015f\u00fcr\u00fcr. Ayr\u0131ca, amilin veya Pramlintide asetat, tip 2 diyabetli hastalarda kilo kayb\u0131yla sonu\u00e7lanan tokluk toklu\u011fu ind\u00fckleme gibi ek bir faydaya sahiptir. Pramlintide asetat mide bo\u015falmas\u0131n\u0131 yava\u015flatt\u0131\u011f\u0131ndan, gastroparezi olan hastalarda ve gastrointestinal motiliteyi de\u011fi\u015ftiren ila\u00e7lar (atropin gibi antikolinerjik ajanlar) veya besinlerin ba\u011f\u0131rsak emilimini yava\u015flatan (\u03b1-glukozidaz inhibit\u00f6rleri gibi) hastalarda kontrendikedir. Pramlintid asetat ayr\u0131ca hipoglisemik e\u011filimleri olan hastalarda kontrendikedir; \u0130ns\u00fclin ile birlikte uygulama nedeniyle, ins\u00fclinin neden oldu\u011fu \u015fiddetli hipoglisemi bir risktir. En s\u0131k bildirilen yan etkiler bulant\u0131, kusma, anoreksi, ba\u015f a\u011fr\u0131s\u0131, kar\u0131n a\u011fr\u0131s\u0131, yorgunluk, ba\u015f d\u00f6nmesi, \u00f6ks\u00fcr\u00fck ve farenjittir.<\/p>\n

CAS 196078-30-5'in \u0130\u015flevi ve Uygulamas\u0131<\/strong> <\/p>\n

Pramlintide asetat, pankreatik amiloid polipeptidin (Amilin, amilopektin) sentetik bir analo\u011fudur ve tip 1 diyabet tedavisinde ins\u00fclinden sonra onaylanan ikinci ila\u00e7t\u0131r. Klinik uygulamada, pramlintid, tip 1 ve tip 2 diyabet tedavisi i\u00e7in, esas olarak tek ba\u015f\u0131na ins\u00fclin ve ins\u00fclin ve s\u00fclfonil\u00fcreler ve metformin kombinasyonu ile beklenen sonu\u00e7lar\u0131 elde edemeyen diyabetli hastalar i\u00e7in adjuvan bir ila\u00e7 olarak kullan\u0131l\u0131r. Pramlintid, ins\u00fclin ile kombinasyon halinde kullan\u0131labilir, ancak ins\u00fclinin yerini alamaz.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u00dcr\u00fcn Ad\u0131: Pramlintide asetat
\nCAS: 196078-30-5
\nMF: C173H273N51O56S2
\nMW: 4027.46
\nMol Dosya: 196078-30-5.mol<\/p>\n","protected":false},"featured_media":2219,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[353],"product_tag":[1297],"class_list":{"0":"post-8384","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-diyabet-peptidi","7":"product_tag-pramlintide-acetate-cas-196078-30-5-is-an-antidiabetic-agent-that-can-also-be-used-in-bowel-cancer-research-tr","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product\/8384","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/comments?post=8384"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/media\/2219"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/media?parent=8384"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product_brand?post=8384"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product_cat?post=8384"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product_tag?post=8384"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}