{"id":8433,"date":"2021-12-16T13:29:10","date_gmt":"2021-12-16T18:29:10","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/sicak-satis-farmasotik-peptitler-pasireotid-cas-396091-73-9\/"},"modified":"2021-12-16T13:29:10","modified_gmt":"2021-12-16T18:29:10","slug":"sicak-satis-farmasotik-peptitler-pasireotid-cas-396091-73-9","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/tr\/product\/sicak-satis-farmasotik-peptitler-pasireotid-cas-396091-73-9\/","title":{"rendered":"S\u0131cak Sat\u0131\u015f Farmas\u00f6tik Peptitler Pasireotid CAS 396091-73-9"},"content":{"rendered":"

S\u0131cak Sat\u0131\u015f Farmas\u00f6tik Peptitler Pasireotid CAS 396091-73-9<\/strong><\/h2>\n

\u00dcr\u00fcn Ad\u0131: PASIREOTIDE
\nE\u015f Anlaml\u0131: PASIREOTIDE;Siklo[(2S)-2-fenilglisil-D-triptofil-L-lisil-O-(fenilmetil)-L-tirosil-L-fenilalanil-(4R)- 4-[[[(2-aminoetil)amino]karbonil]oksi]-L-prolil];SOM 230;SOM 320;[(3S,6S,9S,12R,15S,18S,20R)-9-(4- aminob\u00fctil)-3-benzil-12-(1H-indol-3-ilmetil)-2,5,8,11,14,17-heksaokso-15-fenil-6-[(4-fenilmetoksifenil)metil]-1, 4,7,10,13,16-hekzazabisiklo[16.3.0]henikosan-20-il] N-(2-aminoetil)karbamat;SOM 230;SOM 320;CYCLO((4R)-4-(2-AM\u0130NOET\u0130LKARBAMOYLOKS) -L-PROLYL-L-FENILLGLYCYL-D-TRYPTOPHYL-L-LYSYL-4-O-BENZYL-L-TYROSYL-L-PHENILALANYL-)
\nCAS: 396091-73-9
\nMF: C58H66N10O9<& >MW: 1047.23
\nEINECS:
\n\u00dcr\u00fcn Kategorileri:
\nMol Dosyas\u0131: 396091-73-9.mol<\/p>\n

Nisan 2012'de Avrupa Komisyonu, Cushing Hastal\u0131\u011f\u0131 tedavisi i\u00e7in pasireotidi onaylad\u0131 ( CD) cerrahi m\u00fcdahaleye yan\u0131t vermeyen veya cerrahinin bir se\u00e7enek olmad\u0131\u011f\u0131 eri\u015fkin hastalarda. Pasireotid, Aral\u0131k 2012'de ABD FDA taraf\u0131ndan ayn\u0131 endikasyon i\u00e7in onaylanm\u0131\u015ft\u0131r. Pasireotid (ayr\u0131ca k \u015fimdi SOM230 olarak bilinir), ACTH sal\u0131n\u0131m\u0131n\u0131 inhibe etmek i\u00e7in bir somatostatin analo\u011fu olarak i\u015flev g\u00f6ren bir sikloheksapeptiddir. Somatostatinler, bir inhibit\u00f6r mekanizma yoluyla bir\u00e7ok dokuda endokrin ve ekzokrin sal\u0131n\u0131m\u0131n\u0131n d\u00fczenlenmesinde \u00f6nemli rol oynayan 14 ve 28 amino asitlik siklik peptitlerdir. Somatostatin resept\u00f6rlerinin (SSTR'ler) bilinen be\u015f alt tipi vard\u0131r. Do\u011fal somatostatinler, be\u015f alt tipin t\u00fcm\u00fcne y\u00fcksek afinite ile ba\u011flan\u0131r, ancak bunlar\u0131n terap\u00f6tik kullan\u0131mlar\u0131, plazmadaki h\u0131zl\u0131 bozunma ile s\u0131n\u0131rl\u0131d\u0131r. Pasireotid, uzun s\u00fcreli inhibit\u00f6r etkileri olan bir somatostatinmimeti\u011fi belirleme \u00e7abalar\u0131ndan ortaya \u00e7\u0131km\u0131\u015ft\u0131r. 14 amino asitli bir somatostatin peptidi ile ba\u015flayarak, sistematik bir alanin taramas\u0131, anahtar b-d\u00f6n\u00fc\u015f\u00fc b\u00f6lgeleri ve biti\u015fik tortular dahil olmak \u00fczere resept\u00f6r alt tipi ba\u011flanmas\u0131 i\u00e7in gerekli olan tortular\u0131 ortaya \u00e7\u0131kard\u0131. Temel yap\u0131sal elementlerin bir sikloheksapeptid omurgas\u0131na do\u011fal olmayan amino asitler olarak yerle\u015ftirilmesi pasireotid verdi.<\/p>\n

PASIREOTIDE CAS 396091-73-9<\/strong>
\nKaynama noktas\u0131 1351.4\u00b165.0 \u00b0C(Tahmini)
\nyo\u011funluk 1.36\u00b10.1 g \/cm3(\u00d6ng\u00f6r\u00fclen)
\npka 11.86\u00b10.46(\u00d6ng\u00f6r\u00fclen)
\nCAS Veritaban\u0131 Referans\u0131 396091-73-9<\/p>\n

PASIREOTIDE CAS 396091-73-9'un \u0130\u015flevi ve Uygulamas\u0131<\/strong>
\nB\u00fcy\u00fcme inhibit\u00f6r\u00fc olarak Pasireotidin, hem h\u00fccresel testler hem de hayvan \u00e7al\u0131\u015fmalar\u0131 gibi klinik \u00f6ncesi \u00e7al\u0131\u015fmalarda akromegali, karsinoid t\u00fcm\u00f6rler ve Cushing hastal\u0131\u011f\u0131n\u0131n tedavisinde oktreotid ve lanreotid gibi b\u00fcy\u00fcme inhibit\u00f6r\u00fc analoglar\u0131ndan daha etkili oldu\u011fu g\u00f6sterilmi\u015ftir. klinik denemeler. Pasireotid \u00fczerinde faz II denemesinin ve bir faz III denemesinin sonu\u00e7lar\u0131, pasireotidin yeni veya kal\u0131c\u0131 akromegali ve metastatik karsinoid t\u00fcm\u00f6rler i\u00e7in yeni bir tedavi oldu\u011funu ve Cushing hastal\u0131\u011f\u0131 i\u00e7in ila\u00e7 tedavisinin ilk tercihi olabilece\u011fini do\u011frulam\u0131\u015ft\u0131r.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u00dcr\u00fcn Ad\u0131: PASIREOTIDE
\nMF: C58H66N10O9
\nMW: 1047.23
\nEINECS:
\nMol Dosya: 396091-73-9.mol<\/p>\n","protected":false},"featured_media":2219,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[529],"product_tag":[1256],"class_list":{"0":"post-8433","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-diger-peptitler","7":"product_tag-hot-sale-pharmaceutical-peptidespasireotide-cas-396091-73-9-tr","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product\/8433","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/comments?post=8433"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/media\/2219"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/media?parent=8433"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product_brand?post=8433"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product_cat?post=8433"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product_tag?post=8433"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}