{"id":8589,"date":"2021-12-17T01:48:30","date_gmt":"2021-12-17T06:48:30","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/nesiritide-bnp-32-human-cas-124584-08-3-kalp-yetersizligi-icin-beyin-natriuretik-peptidi\/"},"modified":"2021-12-17T01:48:30","modified_gmt":"2021-12-17T06:48:30","slug":"nesiritide-bnp-32-human-cas-124584-08-3-kalp-yetersizligi-icin-beyin-natriuretik-peptidi","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/tr\/product\/nesiritide-bnp-32-human-cas-124584-08-3-kalp-yetersizligi-icin-beyin-natriuretik-peptidi\/","title":{"rendered":"Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3 Kalp Yetersizli\u011fi i\u00e7in Beyin Natri\u00fcretik Peptidi"},"content":{"rendered":"

Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3 Kalp Yetersizli\u011fi i\u00e7in Beyin Natri\u00fcretik Peptidi<\/strong><\/h2>\n

\u00dcr\u00fcn Ad\u0131: Nesiritide \/ BNP-32 (HUMAN)
\nE\u015f anlaml\u0131lar: Nesiritide,Brain Natriuretic Peptide-32 human,BNP-32, >98%;BNP-32 (insan) hidroklor\u00fcr;Nesiritid [USAN:INN] ;SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH (D\u0130S\u00dcLF\u0130T K\u00d6PR\u00dcS\u00dc: 10-26);SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER -SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS;H-SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY -ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS-OH;H-SER-PRO-LYS -MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL -LEU-ARG-ARG-HIS-OH (D\u0130S\u00dcLF\u0130T K\u00d6PR\u00dcS\u00dc: 10-26);BEY\u0130N DO\u011eAL PEPT\u0130T (1-32), \u0130NSAN
\nCAS: 124584-08-3
\nMF: C143H244N50O42S4
\nMW: 3464.04
\nEINECS: 1312995-182-4
\n\u00dcr\u00fcn Kategorileri:
\nMol Dosyas\u0131: 124584-08-3.mol<\/p>\n

Nesiritid ABD'de yeni bir intraven\u00f6z tedavi olarak ABD'de tan\u0131t\u0131ld\u0131. istirahatte veya minimal aktivitede dispnesi olan akut dekompanse konjestif kalp yetmezli\u011fi i. Nesiritid, g\u00fc\u00e7l\u00fc vazodilat\u00f6r B tipi natri\u00fcretik peptidin (beyin natri\u00fcretik peptidi olarak da bilinir) ilk insan rekombinant formudur, do\u011fal olarak olu\u015fan 32 amino asitli bir peptid ve bir dis\u00fclfid ba\u011fl\u0131 17 amino asit halka yap\u0131s\u0131na sahiptir. Nesiritid, a\u011f\u0131rl\u0131kl\u0131 olarak vask\u00fcler d\u00fcz kas h\u00fccresi gev\u015femesine arac\u0131l\u0131k eden ikinci haberci cGMP'nin \u00fcretimini uyaran endotelyal ve d\u00fcz kas h\u00fccrelerinin y\u00fczeyindeki Atipi natri\u00fcretik peptit resept\u00f6r\u00fcne ba\u011flan\u0131r. Ayr\u0131ca b\u00f6brek taraf\u0131ndan sodyum ve suyun at\u0131lmas\u0131n\u0131 kolayla\u015ft\u0131r\u0131r ve adrenalin, anjiyotensin II, aldosteron ve endotelin gibi kan damar\u0131 daralmas\u0131 ve kan bas\u0131nc\u0131n\u0131n y\u00fckselmesi gibi uzun s\u00fcreli zararl\u0131 etkilere neden olan belirli hormonlar\u0131n salg\u0131lanmas\u0131n\u0131 azalt\u0131r. Kalp yetmezli\u011fi hastalar\u0131yla yap\u0131lan klinik \u00e7al\u0131\u015fmalarda, nesidtid doza ba\u011f\u0131ml\u0131 olarak pulmoner kapiller kama bas\u0131nc\u0131n\u0131, sa\u011f atriyal bas\u0131nc\u0131 ve sistemik vask\u00fcler direnci azaltt\u0131 ve kalp h\u0131z\u0131n\u0131 etkilemeden kardiyak indeksi art\u0131rd\u0131. G\u00f6zlenen en \u00f6nemli yan etki doza ba\u011f\u0131ml\u0131 hipotansiyondur. Bir faz III kar\u015f\u0131la\u015ft\u0131rmal\u0131 denemede, nesiritid'in iv'den daha \u00fcst\u00fcn oldu\u011fu bulundu. nitrogliserin hemodinamik etkilerinin yan\u0131 s\u0131ra uygulanmas\u0131 daha kolay ve daha iyi tolere edilir. Nesiritid, enzim n\u00f6tr endopeptidaz NEP24.11 taraf\u0131ndan proteolitik b\u00f6l\u00fcnme ve C-tipi natri\u00fcretik peptit resept\u00f6r\u00fcne ba\u011flanma ve ard\u0131ndan endositoz ve h\u00fccre i\u00e7i lizozomal hidroliz yoluyla temizlenir. K\u0131sa bir yar\u0131 \u00f6mre (18 dakika) sahip oldu\u011fundan, nesiritid 21\u03bcg\/kg bolus inf\u00fczyonu olarak uygulan\u0131r, ard\u0131ndan genellikle 24-48 saat boyunca 0.011\u03bcg\/kg\/dk'l\u0131k s\u00fcrekli bir idame inf\u00fczyonu yap\u0131l\u0131r.<\/p>\n

Nesiritid \/ BNP-32 (\u0130NSAN) CAS 124584-08-3 Kimyasal \u00d6zellikler<\/strong>
\nBNP-32 (\u0130NSAN) Kimyasal \u00d6zellikler
\nyo\u011funluk 1,52\u00b10,1 g\/cm3(\u00d6ng\u00f6r\u00fclen)
\nRTECS EE1534000
\ndepolama s\u0131cakl\u0131\u011f\u0131. \u221220\u00b0C
\ntoz halinde
\nSuda \u00c7\u00f6z\u00fcn\u00fcrl\u00fck Suda 1mg\/ml'de \u00e7\u00f6z\u00fcn\u00fcr
\nCAS Veri Taban\u0131 Referans\u0131 124584-08-3<\/p>\n

Nesiritid \/ BNP-32'nin \u0130\u015flevi ve Uygulamas\u0131 (\u0130NSAN) CAS 124584-08-3<\/strong>
\nKonjestif kalp yetmezli\u011finin tedavisi (renin-anjiyotensin sistem antagonisti).<\/p>\n","protected":false},"excerpt":{"rendered":"

\u00dcr\u00fcn Ad\u0131: Nesiritide \/ BNP-32 (\u0130NSAN)
\nCAS: 124584-08-3
\nMF: C143H244N50O42S4
\nMW: 3464.04
\nEINECS: 1312995-182-4
\n\u00dcr\u00fcn Kategorileri: < &>Mol Dosyas\u0131: 124584-08-3.mol<\/p>\n","protected":false},"featured_media":2303,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[507],"product_tag":[1149],"class_list":{"0":"post-8589","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-kardiyovaskuler-sistem-peptidi","7":"product_tag-nesiritide-bnp-32-human-cas-124584-08-3-brain-natriuretic-peptide-for-heart-failure-tr","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product\/8589","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/comments?post=8589"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/media\/2303"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/media?parent=8589"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product_brand?post=8589"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product_cat?post=8589"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product_tag?post=8589"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}