{"id":8648,"date":"2021-12-17T01:51:51","date_gmt":"2021-12-17T06:51:51","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/glukagon-cas-16941-32-5-kan-sekerini-yukseltmek-icin-glikojenolizi-ve-glikoz-uretimini-tesvik-eder\/"},"modified":"2021-12-17T01:51:51","modified_gmt":"2021-12-17T06:51:51","slug":"glukagon-cas-16941-32-5-kan-sekerini-yukseltmek-icin-glikojenolizi-ve-glikoz-uretimini-tesvik-eder","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/tr\/product\/glukagon-cas-16941-32-5-kan-sekerini-yukseltmek-icin-glikojenolizi-ve-glikoz-uretimini-tesvik-eder\/","title":{"rendered":"Glukagon CAS 16941-32-5 Kan \u015fekerini y\u00fckseltmek i\u00e7in glikojenolizi ve glikoz \u00fcretimini te\u015fvik eder"},"content":{"rendered":"

Glukagon CAS 16941-32-5 Kan \u015fekerini y\u00fckseltmek i\u00e7in glikojenolizi ve glikoz \u00fcretimini te\u015fvik eder<\/strong><\/h2>\n

\u00dcr\u00fcn Ad\u0131: Glukagon
\nE\u015f Anlaml\u0131lar: GLUCAGON 1-37;GLUCAGON (1-37) (PORS\u0130NE);GLUCAGON 37;GLUCAGON ASETAT;HSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNKNNIA;H-HIS-SER-GLN-GLY-THR-PHE- -SER-ASP-TYR-SER-LYS-TYR-LEU-ASP-SER-ARG-ARG-ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR-LYS-ARG-ASN -LYS-ASN-ASN-ILE-ALA-OH;Glukagon 1-29;Glukagon(1-29) \u0130nsan HCl
\nCAS: 16941-32-5
\nMF: C153H225N43O49S
\nMW: 3482.75<& >EINECS: 685-611-6
\n\u00dcr\u00fcn Kategorileri: Amino Asit T\u00fcrevleri;Peptid;GlukagonAdac\u0131k K\u00f6k H\u00fccre Biyolojisi;Adac\u0131k K\u00f6k H\u00fccre Farkl\u0131la\u015fmas\u0131;Hormonlar;Di\u011fer Protein\/Peptid Hormonlar\u0131;Glukagon ve Glukagon Benzeri PeptitlerH\u00fccre Biyolojisi \u0130\u00e7in Peptitler;Glukagonlar H\u00fccre Biyolojisi;Sitokinler B\u00fcy\u00fcme Fakt\u00f6rleri ve Hormonlar (Obezite);Gastrointestinal Peptitler;GlukagonObezite Ara\u015ft\u0131rmas\u0131;API;Diyabet Ara\u015ft\u0131rmas\u0131
\nMol Dosya: 16941-32-5.mol<\/p>\n

Glukagon olarak da bilinen Glukagon, bir 29 amino asit i\u00e7eren, molek\u00fcler form\u00fcl\u00fc ve ba\u011f\u0131l molek\u00fcler form\u00fcl\u00fc olan pankreas adac\u0131k \u03b1 h\u00fccreleri taraf\u0131ndan salg\u0131lanan d\u00fcz zincirli polipeptit hormonu C153H225N43O49S'nin k\u00fctlesi = 3482.8. \u00c7in bu hormonu sentezledi. Oda s\u0131cakl\u0131\u011f\u0131nda beyaz, kokusuz ve tats\u0131z bir t\u00fcr ince kristal tozdur. Glukagon, suda ve \u00e7o\u011fu organik \u00e7\u00f6z\u00fcc\u00fcde hemen hemen \u00e7\u00f6z\u00fcnmezken, seyreltik asit ve seyreltik alkali \u00e7\u00f6zeltisinde \u00e7\u00f6z\u00fcn\u00fcr. Preparat\u0131n \u00e7o\u011fu suda \u00e7\u00f6z\u00fcnen hidroklor\u00fcrd\u00fcr. Glukagonun fizyolojik aktivitesini g\u00f6sterebilmesi i\u00e7in molek\u00fcler b\u00fct\u00fcnl\u00fc\u011f\u00fcn\u00fc korumas\u0131 gerekti\u011fi bilinmektedir. \u0130nsan ve memelinin (tav\u015fan, s\u0131\u011f\u0131r, domuz, s\u0131\u00e7an vb.) glukagon yap\u0131s\u0131, ku\u015flarda biraz farkl\u0131 olsa da tutarl\u0131 olabilir.<\/p>\n

Glukagon, 29 amino asitten olu\u015fan bir polipeptittir ve alfa h\u00fccreleri taraf\u0131ndan salg\u0131lan\u0131r. pankreas adac\u0131klar\u0131ndan. Glukagon, ba\u015flang\u0131\u00e7ta glukagon olu\u015fturmak \u00fczere pankreas alfa h\u00fccrelerinde ve GLP-1 ve GLP-2'yi olu\u015fturmak \u00fczere ba\u011f\u0131rsak h\u00fccrelerinde dokuya \u00f6zg\u00fc olarak i\u015flenen, \u00f6nc\u00fcl pro-glukagon olarak pro-glukagon geninden \u00fcretilir.
\n<& >Genel olarak ins\u00fclin ve glukagonun diyabet patofizyolojisinde rol oynayan ana hormonlar oldu\u011fu kabul edilir, ancak glukagonun diyabetteki rol\u00fc baz\u0131 durumlarda karma\u015f\u0131k ve tart\u0131\u015fmal\u0131d\u0131r. Halihaz\u0131rda kullan\u0131lan hipoglisemik ajanlarda glukagonun rol\u00fc artan bir ilgi g\u00f6rmektedir ve glukagon hedefli tedavinin devam eden geli\u015fimi, diyabet y\u00f6netiminin optimize edilmesinde glukagonun \u00f6nemli katk\u0131s\u0131n\u0131 vurgulamaktad\u0131r.<\/p>\n

Glukagon, hepatik glikozu uyaran bir kar\u015f\u0131 d\u00fczenleyici hormondur. hipoglisemi \u00f6nlemek i\u00e7in \u00fcretim. Glukagon resept\u00f6rleri hepatositlerde bulunur ve b\u00f6brek, kalp, gastrointestinal sistem, ya\u011f dokusu, beyin ve dalakta da glukagon ba\u011flama b\u00f6lgeleri tan\u0131mlanm\u0131\u015ft\u0131r. K\u00f6peklerde yap\u0131lan \u00e7al\u0131\u015fmalara g\u00f6re, glukagonun yakla\u015f\u0131k %17'si b\u00f6brekler taraf\u0131ndan ve %20 ila %25'i karaci\u011ferde y\u0131k\u0131lmaktad\u0131r. Hipoglisemiye yan\u0131t olarak glukagon sal\u0131n\u0131m\u0131 iyi bilinmektedir ve otonomik, endokrin ve parakrin mekanizmalar arac\u0131l\u0131\u011f\u0131yla ve muhtemelen ayr\u0131ca alfa h\u00fccreleri taraf\u0131ndan kan glukoz seviyelerinin do\u011frudan alg\u0131lanmas\u0131 yoluyla arac\u0131l\u0131k edilir. H\u00fccrelerin glukagon salg\u0131lad\u0131\u011f\u0131 kesin molek\u00fcler mekanizmalar tam olarak anla\u015f\u0131lmam\u0131\u015ft\u0131r, ancak potasyum adenozin trifosfat (KATP) kanallar\u0131 ve kalsiyum kanallar\u0131n\u0131 i\u00e7erir.<\/p>\n

Normal fizyolojide, hiperglisemi s\u0131ras\u0131nda glukagon salg\u0131lanmas\u0131 h\u00fccresel salg\u0131 \u00fcr\u00fcnleri ins\u00fclin taraf\u0131ndan inhibe edilir, yemeklere ve y\u00fcksek kan \u015fekerine yan\u0131t olarak sal\u0131nan \u00e7inko ve gama-aminob\u00fctirik asit (GABA). Kan \u015fekeri seviyeleri d\u00fc\u015ft\u00fc\u011f\u00fcnde, beta h\u00fccreleri bu \u00fcr\u00fcnlerin \u00fcretimini azalt\u0131r, b\u00f6ylece alfa h\u00fccreleri \u00fczerindeki inhibit\u00f6r etkilerini ortadan kald\u0131r\u0131r. "Kapatma" hipotezi olarak bilinen bu mekanizma, sonu\u00e7ta kan \u015fekeri \u00e7ok d\u00fc\u015f\u00fck oldu\u011funda glukagon salg\u0131s\u0131nda bir art\u0131\u015fa yol a\u00e7ar. Adac\u0131klarda \u03b4 h\u00fccreleri ve GLP-1 taraf\u0131ndan \u00fcretilen b\u00fcy\u00fcmeyi \u00f6nleyici hormon da glukagon salg\u0131lanmas\u0131n\u0131 engeller.<\/p>\n

Hem tip 1 diyabet (T1DM) hem de tip 2 diyabet (T2DM)'de plazma glukagon seviyeleri \u00e7ok y\u00fcksek. Hepatik glukoz \u00fcretimini destekleyen d\u00fczenleyici bir hormon olan glukagon, normal fizyolojik ko\u015fullar alt\u0131nda hipoglisemiyi \u00f6nler. Diyabetli hastalarda glukagon salg\u0131lanmas\u0131 kontrols\u00fcz olabilir ve bu da glukoz homeostaz\u0131nda sorunlara yol a\u00e7ar. Diyabet i\u00e7in baz\u0131 tedaviler, glukagonun salg\u0131lanmas\u0131n\u0131 veya etkisini ve ayr\u0131ca glukagona \u00f6zg\u00fc hedefli tedaviyi inhibe ederek etkilidir.<\/p>\n

Glukagon CAS 16941-32-5 Kimyasal \u00d6zellikler<\/strong>
\nyo\u011funluk 1,53\u00b10,1 g\/cm3( Tahmini)
\ndepolama s\u0131cakl\u0131\u011f\u0131. Karanl\u0131k bir yerde saklay\u0131n,Kuruda kapat\u0131n,2-8\u00b0C
\n\u00e7\u00f6z\u00fcn\u00fcrl\u00fck Suda ve \u00e7o\u011fu organik \u00e7\u00f6z\u00fcc\u00fcde pratik olarak \u00e7\u00f6z\u00fcnmez. Seyreltik mineral asitlerde ve alkali hidroksitlerin seyreltik \u00e7\u00f6zeltilerinde \u00e7\u00f6z\u00fcn\u00fcr.
\ntoz olu\u015fturur<\/p>\n

Glukagon CAS 16941-32-5'in \u0130\u015flevi ve Uygulamas\u0131<\/strong>
\n1\u3001Kan \u015fekeri etkisini art\u0131r\u0131r: Aktive edebilir karaci\u011fer fosforilaz, hepatik glikojen ayr\u0131\u015fmas\u0131n\u0131 ve glikojen izogenezini te\u015fvik eder ve kan \u015fekerini y\u00fckseltir.
\n2\u3001Pozitif inotropik etki: H\u00fccre i\u00e7i cAMP i\u00e7eri\u011fini art\u0131rabilir, miyokardiyal kontraktiliteyi art\u0131rabilir, kalp debisini ve at\u0131m ba\u015f\u0131na i\u015fi art\u0131rabilir. Yeterli miktarda kardiyak glikozit uyguland\u0131ktan sonra da pozitif inotropik etkisi devam edebilir ve propranolol taraf\u0131ndan bloke edilmez. Kalp at\u0131\u015f h\u0131z\u0131n\u0131 ve kan bas\u0131nc\u0131n\u0131 art\u0131rabilmesine ra\u011fmen aritmiye neden olmaz. Mekanizmalar \u015funlard\u0131r: (1) miyokardiyal kontraktiliteyi art\u0131ran adenozin trifosfat\u0131 siklize adenosin monofosfata d\u00f6n\u00fc\u015ft\u00fcrmek i\u00e7in adenilat siklaz\u0131 aktive etmek; (2) hepatik glikojenolizi te\u015fvik etmek ve kan \u015fekeri seviyesini y\u00fckseltmek; (3) ins\u00fclin sal\u0131n\u0131m\u0131n\u0131 te\u015fvik etmek Chemicalbook sal\u0131n\u0131m\u0131n\u0131 te\u015fvik etmek, glikozun miyokardiyal kullan\u0131m\u0131n\u0131 iyile\u015ftirmek ve miyokardiyal anaerobik enzimleri desteklemek, b\u00f6ylece miyokardiyal enerji metabolizmas\u0131n\u0131 geli\u015ftirmek. Digitalis benzeri kardiyak glikozitlerle birlikte etkinli\u011fi art\u0131rabilir.
\n3. B\u00f6brek \u00fczerindeki etkiler: b\u00f6brek kan damarlar\u0131n\u0131 geni\u015fletir, b\u00f6brek kan ak\u0131\u015f\u0131n\u0131 iyile\u015ftirir ve sodyum, potasyum ve kalsiyum at\u0131l\u0131m\u0131n\u0131 destekler.
\n4. Sindirim sistemi \u00fczerindeki etkileri: Mide ve on iki parmak ba\u011f\u0131rsa\u011f\u0131, ince ba\u011f\u0131rsak ve kolon d\u00fcz kaslar\u0131n\u0131n gev\u015femesine neden olabilir, mide, ince ba\u011f\u0131rsak ve kolonun peristaltizmini inhibe edebilir, safra ve ba\u011f\u0131rsak s\u0131v\u0131s\u0131n\u0131n salg\u0131lanmas\u0131n\u0131 art\u0131rabilir.
\n5. Salg\u0131 sistemi \u00fczerindeki etkileri: adrenal medullay\u0131 heyecanland\u0131r\u0131r, katekolaminlerin sal\u0131n\u0131m\u0131n\u0131 te\u015fvik eder. Ayr\u0131ca ins\u00fclin, tiroid hormonu, kalsitonin ve b\u00fcy\u00fcme hormonunun salg\u0131lanmas\u0131n\u0131 da te\u015fvik edebilir.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u00dcr\u00fcn Ad\u0131: Glukagon
\nCAS: 16941-32-5
\nMF: C153H225N43O49S
\nMW: 3482.75
\nEINECS: 685-611-6
\nMol Dosya: 16941-32-5.mol<\/p>\n","protected":false},"featured_media":2135,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[353],"product_tag":[1098],"class_list":{"0":"post-8648","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-diyabet-peptidi","7":"product_tag-glucagon-cas-16941-32-5-promotes-glycogenolysis-and-glucose-production-to-raise-blood-sugar-tr","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product\/8648","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/comments?post=8648"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/media\/2135"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/media?parent=8648"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product_brand?post=8648"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product_cat?post=8648"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/tr\/wp-json\/wp\/v2\/product_tag?post=8648"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}