{"id":7278,"date":"2021-12-16T07:20:10","date_gmt":"2021-12-16T12:20:10","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-doi-voi-chong-hiv\/"},"modified":"2021-12-16T07:20:10","modified_gmt":"2021-12-16T12:20:10","slug":"enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-doi-voi-chong-hiv","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/vi\/product\/enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-doi-voi-chong-hiv\/","title":{"rendered":"Enfuvirtide \/ Enfuvirtide Acetate CAS 159519-65-0 \u0110\u1ed1i v\u1edbi Ch\u1ed1ng HIV"},"content":{"rendered":"

Enfuvirtide \/ Enfuvirtide Acetate CAS 159519-65-0 \u0110\u1ed1i v\u1edbi Ch\u1ed1ng HIV<\/strong><\/h2>\n

T\u00ean s\u1ea3n ph\u1ea9m: Enfuvirtide
\n Tr\u00ecnh t\u1ef1: Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys < &> – Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
\n T\u1eeb \u0111\u1ed3ng ngh\u0129a: Enfuvirtide; T-2; Enfuvirtide Acetate (T-20); ENFUVIRTIDE (T-20) 98 +%; Enfurvitide (T-20); Pentafuside; Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile -Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn -Trp-Phe-NH {2}; Enfuvirtide; Aids059486
\n CAS: 159519-65-0
\n MF: C204H301N51O64
\n MW: 4491,92
\n EINECS: 641-385-0
\n Danh m\u1ee5c s\u1ea3n ph\u1ea9m : protein; Peptide
\n Mol File: 159519-65-0.mol <\/p>\n

N\u00f3 l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf peptit t\u1ed5ng h\u1ee3p c\u1ee7a qu\u00e1 tr\u00ecnh dung h\u1ee3p HIV, c\u00f3 th\u1ec3 li\u00ean k\u1ebft v\u1edbi glycoprotein trong v\u1ecf vi r\u00fat v\u00e0 ng\u0103n ch\u1eb7n nh\u1eefng thay \u0111\u1ed5i c\u1ea5u tr\u00fac c\u1ea7n thi\u1ebft cho vi r\u00fat \u0111\u1ec3 h\u1ee3p nh\u1ea5t v\u1edbi m\u00e0ng t\u1ebf b\u00e0o, do \u0111\u00f3 \u1ee9c ch\u1ebf s\u1ef1 sao ch\u00e9p c\u1ee7a HIV-1.Enfevir peptit c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb tr\u00ecnh t\u1ef1 axit amin xu\u1ea5t hi\u1ec7n t\u1ef1 nhi\u00ean trong v\u00f9ng HR2 c\u1ee7a gp41. B\u1eb1ng c\u00e1ch m\u00f4 ph\u1ecfng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a mi\u1ec1n HR2 v\u00e0 li\u00ean k\u1ebft c\u1ea1nh tranh v\u1edbi mi\u1ec1n HR1 c\u1ee7a gp41, Enfevir peptide ng\u0103n ch\u1eb7n s\u1ef1 t\u01b0\u01a1ng t\u00e1c gi\u1eefa HR1 v\u00e0 HR2 v\u00e0 nh\u1eefng thay \u0111\u1ed5i trong c\u1ea5u h\u00ecnh c\u1ee7a Gp41, do \u0111\u00f3 ng\u0103n ch\u1eb7n s\u1ef1 h\u1ee3p nh\u1ea5t c\u1ee7a vi r\u00fat v\u1edbi c\u00e1c t\u1ebf b\u00e0o ch\u1ee7. <\/p>\n

Enfuvirtide l\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb \u0111\u1ea7u ti\u00ean trong nh\u00f3m \u0111i\u1ec1u tr\u1ecb HIV m\u1edbi can thi\u1ec7p v\u00e0o s\u1ef1 x\u00e2m nh\u1eadp c\u1ee7a HIV-1 b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf s\u1ef1 h\u1ee3p nh\u1ea5t c\u1ee7a virus v\u00e0 m\u00e0ng t\u1ebf b\u00e0o. N\u00f3 li\u00ean k\u1ebft v\u1edbi heptad-repeat \u0111\u1ea7u ti\u00ean (HR1) trong ti\u1ec3u \u0111\u01a1n v\u1ecb ghe gp41 c\u1ee7a glycoprotein v\u1ecf virus v\u00e0 ng\u0103n ch\u1eb7n nh\u1eefng thay \u0111\u1ed5i c\u1ea5u tr\u00fac c\u1ea7n thi\u1ebft cho s\u1ef1 h\u1ee3p nh\u1ea5t v\u1edbi m\u00e0ng t\u1ebf b\u00e0o, do \u0111\u00f3 \u0111\u1ea1i di\u1ec7n cho m\u1ed9t c\u01a1 ch\u1ebf m\u1edbi. N\u00f3 l\u00e0 m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf m\u1ea1nh s\u1ef1 g\u1eafn k\u1ebft n\u00e0y v\u1edbi IC50 trong ph\u00f2ng th\u00ed nghi\u1ec7m v\u00e0 c\u00e1c ph\u00e2n l\u1eadp s\u01a1 c\u1ea5p (HIV-1 ph\u00e2n nh\u00f3m A \u2013 G) n\u1eb1m trong kho\u1ea3ng t\u1eeb 4 \u0111\u1ebfn 280 nM (18\u20131260 ng \/ mL), nh\u01b0ng h\u1ea7u nh\u01b0 kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh ch\u1ed1ng l\u1ea1i HIV-2. Do c\u01a1 ch\u1ebf \u0111\u1ed9c \u0111\u00e1o c\u1ee7a n\u00f3, n\u00f3 kh\u00f4ng cho th\u1ea5y s\u1ef1 \u0111\u1ec1 kh\u00e1ng ch\u00e9o v\u1edbi NRTI, NNRTI v\u00e0 PI. N\u00f3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u ch\u1ebf b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p t\u1ed5ng h\u1ee3p h\u00f3a h\u1ecdc, s\u1eed d\u1ee5ng s\u1ef1 k\u1ebft h\u1ee3p c\u1ee7a dung d\u1ecbch v\u00e0 c\u00e1c b\u01b0\u1edbc pha r\u1eafn. C\u00e1c b\u01b0\u1edbc pha r\u1eafn s\u1eed d\u1ee5ng b\u1ea3o v\u1ec7 fmoc v\u00e0 nh\u1ef1a clorua 2 – chlorotrityl nh\u1ea1y c\u1ea3m v\u1edbi axit \u0111\u1ec3 t\u1ea1o ra c\u00e1c peptit c\u00f3 \u0111\u1ed9 d\u00e0i t\u1eeb ch\u00edn \u0111\u1ebfn m\u01b0\u1eddi s\u00e1u axit amin. <\/p>\n

Enfuvirtide \/ Enfuvirtide Acetate CAS 159519-65-0 Thu\u1ed9c t\u00ednh h\u00f3a h\u1ecdc<\/strong>
\n nhi\u1ec7t \u0111\u1ed9 l\u01b0u tr\u1eef. -20 \u00b0 C
\n d\u1ea1ng b\u1ed9t
\n m\u00e0u tr\u1eafng \u0111\u1ebfn tr\u1eafng nh\u1ea1t <\/p>\n

C\u00f4ng d\u1ee5ng c\u1ee7a Enfuvirtide \/ Enfuvirtide Acetate CAS 159519-65-0<\/strong>
\n N\u00f3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c sao ch\u00e9p ng\u01b0\u1ee3c cho ng\u01b0\u1eddi nhi\u1ec5m vi r\u00fat suy gi\u1ea3m mi\u1ec5n d\u1ecbch (HIV).<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00ean s\u1ea3n ph\u1ea9m: Enfuvirtide
\n CAS: 159519-65-0
\n MF: C204H301N51O64
\n MW: 4491,92
\n EINECS: 641-385-0
\n Mol T\u1ec7p: 159519-65-0.mol<\/p>\n","protected":false},"featured_media":2136,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[],"product_tag":[2512],"class_list":{"0":"post-7278","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_tag-enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-for-anti-hiv-vi","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/product\/7278","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/comments?post=7278"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/media\/2136"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/media?parent=7278"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/product_brand?post=7278"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/product_cat?post=7278"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/product_tag?post=7278"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}