{"id":8436,"date":"2021-12-16T13:29:11","date_gmt":"2021-12-16T18:29:11","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/ban-nong-peptide-duoc-pham-pasireotide-cas-396091-73-9\/"},"modified":"2021-12-16T13:29:11","modified_gmt":"2021-12-16T18:29:11","slug":"ban-nong-peptide-duoc-pham-pasireotide-cas-396091-73-9","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/vi\/product\/ban-nong-peptide-duoc-pham-pasireotide-cas-396091-73-9\/","title":{"rendered":"B\u00e1n n\u00f3ng Peptide d\u01b0\u1ee3c ph\u1ea9m Pasireotide CAS 396091-73-9"},"content":{"rendered":"

B\u00e1n n\u00f3ng Peptide d\u01b0\u1ee3c ph\u1ea9m Pasireotide CAS 396091-73-9<\/strong><\/h2>\n

T\u00ean s\u1ea3n ph\u1ea9m: PASIREOTIDE
\n T\u1eeb \u0111\u1ed3ng ngh\u0129a: PASIREOTIDE; Cyclo [(2S) -2-phenylglycyl-D-tryptophyl-L-lysyl-O- (phenylmethyl) -L-tyrosyl-L-phenylalanyl- (4R) – 4 – [[[(2-aminoetyl) amino] cacbonyl] oxy] -L-prolyl]; SOM 230; SOM 320; [(3S, 6S, 9S, 12R, 15S, 18S, 20R) -9- (4 – aminobutyl) -3-benzyl-12- (1H-indol-3-ylmetyl) -2,5,8,11,14,17-hexaoxo-15-phenyl-6 – [(4-phenylmethoxyphenyl) metyl] -1, 4,7,10,13,16-hexazabicyclo [16.3.0] henicosan-20-yl] N- (2-aminoetyl) cacbamat; SOM 230; SOM 320; CYCLO ((4R) -4- (2-AMINOETHYLCARBAMOYLOXY) -L-PROLYL-L-PHENYLGLYCYL-D-TRYPTOPHYL-L-LYSYL-4-O-BENZYL-L-TYROSYL-L-PHENYLALANYL -)
\n CAS: 396091-73-9
\n MF: C58H66N10O9 <& > MW: 1047,23
\n EINECS:
\n Danh m\u1ee5c s\u1ea3n ph\u1ea9m:
\n Mol File: 396091-73-9.mol <\/p>\n

V\u00e0o th\u00e1ng 4 n\u0103m 2012, \u1ee6y ban Ch\u00e2u \u00c2u \u0111\u00e3 ph\u00ea duy\u1ec7t pasireotide \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh Cushing ( CD) \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n ng\u01b0\u1eddi l\u1edbn kh\u00f4ng \u0111\u00e1p \u1ee9ng v\u1edbi can thi\u1ec7p ph\u1eabu thu\u1eadt v\u00ec ph\u1eabu thu\u1eadt kh\u00f4ng ph\u1ea3i l\u00e0 d\u1ea5u hi\u1ec7u \u1ea9n. nown as SOM230) l\u00e0 m\u1ed9t cyclohexapeptide ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t ch\u1ea5t t\u01b0\u01a1ng t\u1ef1 somatostatin \u0111\u1ec3 \u1ee9c ch\u1ebf s\u1ef1 gi\u1ea3i ph\u00f3ng ACTH. Somatostatins l\u00e0 c\u00e1c peptit theo chu k\u1ef3 g\u1ed3m 14 v\u00e0 28 axit amin \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c \u0111i\u1ec1u h\u00f2a s\u1ef1 gi\u1ea3i ph\u00f3ng n\u1ed9i ti\u1ebft v\u00e0 n\u1ed9i ti\u1ebft trong nhi\u1ec1u m\u00f4 th\u00f4ng qua c\u01a1 ch\u1ebf \u1ee9c ch\u1ebf. C\u00f3 n\u0103m lo\u1ea1i ph\u1ee5 \u0111\u00e3 bi\u1ebft c\u1ee7a c\u00e1c th\u1ee5 th\u1ec3 somatostatin (SSTR). C\u00e1c somatostatins t\u1ef1 nhi\u00ean li\u00ean k\u1ebft v\u1edbi \u00e1i l\u1ef1c cao v\u1edbi t\u1ea5t c\u1ea3 n\u0103m ph\u00e2n nh\u00f3m, tuy nhi\u00ean, vi\u1ec7c s\u1eed d\u1ee5ng \u0111i\u1ec1u tr\u1ecb c\u1ee7a ch\u00fang b\u1ecb h\u1ea1n ch\u1ebf b\u1edfi s\u1ef1 ph\u00e2n h\u1ee7y nhanh ch\u00f3ng trong huy\u1ebft t\u01b0\u01a1ng. Pasireotide ph\u00e1t sinh c\u00e1c ph\u1ea3n \u1ee9ng bi\u1ebfn \u0111\u1ed5i \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh ch\u1ea5t g\u00e2y nghi\u1ec7n c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf k\u00e9o d\u00e0i. B\u1eaft \u0111\u1ea7u v\u1edbi peptit somatostatin 14 axit amin, qu\u00e1 tr\u00ecnh qu\u00e9t alanin c\u00f3 h\u1ec7 th\u1ed1ng cho th\u1ea5y c\u00e1c g\u1ed1c c\u1ea7n thi\u1ebft cho s\u1ef1 li\u00ean k\u1ebft lo\u1ea1i ph\u1ee5 c\u1ee7a th\u1ee5 th\u1ec3, bao g\u1ed3m c\u00e1c v\u00f9ng chuy\u1ec3n h\u01b0\u1edbng b ch\u00ednh v\u00e0 c\u00e1c g\u1ed1c l\u00e2n c\u1eadn. Vi\u1ec7c \u0111\u1eb7t c\u00e1c y\u1ebfu t\u1ed1 c\u1ea5u tr\u00fac quan tr\u1ecdng d\u01b0\u1edbi d\u1ea1ng axit amin kh\u00f4ng t\u1ef1 nhi\u00ean trong x\u01b0\u01a1ng s\u1ed1ng xyclohexapeptit \u0111\u00e3 t\u1ea1o ra pasireotide. <\/p>\n

PASIREOTIDE CAS 396091-73-9<\/strong>
\n \u0110i\u1ec3m s\u00f4i 1351,4 \u00b1 65,0 \u00b0 C (D\u1ef1 \u0111o\u00e1n)
\n m\u1eadt \u0111\u1ed9 1,36 \u00b1 0,1 g \/ cm3 (D\u1ef1 \u0111o\u00e1n)
\n pka 11,86 \u00b1 0,46 (D\u1ef1 \u0111o\u00e1n)
\n CAS DataBase Tham chi\u1ebfu 396091-73-9 <\/p>\n

Ch\u1ee9c n\u0103ng v\u00e0 \u1ee8ng d\u1ee5ng c\u1ee7a PASIREOTIDE CAS 396091-73-9<\/strong>
\n L\u00e0m ch\u1ea5t \u1ee9c ch\u1ebf t\u0103ng tr\u01b0\u1edfng ch\u1ea5t t\u01b0\u01a1ng t\u1ef1 li\u00ean k\u1ebft v\u1edbi nhi\u1ec1u th\u1ee5 th\u1ec3, pasireotide \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 hi\u1ec7u qu\u1ea3 h\u01a1n c\u00e1c ch\u1ea5t t\u01b0\u01a1ng t\u1ef1 \u1ee9c ch\u1ebf t\u0103ng tr\u01b0\u1edfng nh\u01b0 octreotide v\u00e0 lanreotide trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh to c\u1ef1c, kh\u1ed1i u carcinoid v\u00e0 b\u1ec7nh Cushing, c\u1ea3 trong c\u00e1c th\u1eed nghi\u1ec7m ti\u1ec1n l\u00e2m s\u00e0ng nh\u01b0 x\u00e9t nghi\u1ec7m t\u1ebf b\u00e0o v\u00e0 nghi\u00ean c\u1ee9u tr\u00ean \u0111\u1ed9ng v\u1eadt, v\u00e0 trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng. K\u1ebft qu\u1ea3 c\u1ee7a th\u1eed nghi\u1ec7m pha II v\u00e0 m\u1ed9t th\u1eed nghi\u1ec7m pha III tr\u00ean pasireotide \u0111\u00e3 x\u00e1c nh\u1eadn r\u1eb1ng pasireotide l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi cho c\u00e1c kh\u1ed1i u carcinoid di c\u0103n v\u00e0 to dai d\u1eb3ng m\u1edbi ho\u1eb7c dai d\u1eb3ng, v\u00e0 c\u00f3 th\u1ec3 l\u00e0 l\u1ef1a ch\u1ecdn \u0111\u1ea7u ti\u00ean trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh Cushing.<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00ean s\u1ea3n ph\u1ea9m: PASIREOTIDE
\n MF: C58H66N10O9
\n MW: 1047.23
\n EINECS:
\n Mol T\u1ec7p: 396091-73-9.mol<\/p>\n","protected":false},"featured_media":2220,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[],"product_tag":[1258],"class_list":{"0":"post-8436","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_tag-hot-sale-pharmaceutical-peptidespasireotide-cas-396091-73-9-vi","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/product\/8436","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/comments?post=8436"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/media\/2220"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/media?parent=8436"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/product_brand?post=8436"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/product_cat?post=8436"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/product_tag?post=8436"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}