{"id":8584,"date":"2021-12-17T01:48:28","date_gmt":"2021-12-17T06:48:28","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/nesiritide-bnp-32-con-nguoi-cas-124584-08-3-peptide-natriuretic-cua-nao-cho-benh-suy-tim\/"},"modified":"2021-12-17T01:48:28","modified_gmt":"2021-12-17T06:48:28","slug":"nesiritide-bnp-32-con-nguoi-cas-124584-08-3-peptide-natriuretic-cua-nao-cho-benh-suy-tim","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/vi\/product\/nesiritide-bnp-32-con-nguoi-cas-124584-08-3-peptide-natriuretic-cua-nao-cho-benh-suy-tim\/","title":{"rendered":"Nesiritide \/ BNP-32 (CON NG\u01af\u1edcI) CAS 124584-08-3 Peptide Natriuretic c\u1ee7a n\u00e3o cho b\u1ec7nh suy tim"},"content":{"rendered":"<h2><strong>Nesiritide \/ BNP-32 (CON NG\u01af\u1edcI) CAS 124584-08-3 Peptide Natriuretic c\u1ee7a n\u00e3o cho b\u1ec7nh suy tim<\/strong><\/h2>\n<p> T\u00ean s\u1ea3n ph\u1ea9m: Nesiritide \/ BNP-32 (HUMAN)<br \/>\n T\u1eeb \u0111\u1ed3ng ngh\u0129a: Nesiritide, Brain Natriuretic Peptide-32 ng\u01b0\u1eddi, BNP-32,&gt; 98%; BNP-32 (ng\u01b0\u1eddi) hydrochloride; Nesiritide [USAN: INN] ; SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH (C\u1ea6U KH\u00d4NG M\u1ede R\u1ed8NG: 10-26); SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER -SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS; H-SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY -ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS-OH; H-SER-PRO-LYS -MET-VAN-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL -LEU-ARG-ARG-HIS-OH (C\u1ea6U DI\u1ec6T M\u1ed0I: 10-26); BRAIN NATRIURETIC PEPTIDE (1-32), CON NG\u01af\u1edcI<br \/>\n CAS: 124584-08-3<br \/>\n MF: C143H244N50O42S4<br \/>\n MW: 3464.04<br \/>\n EINECS: 1312995-182-4<br \/>\n Danh m\u1ee5c s\u1ea3n ph\u1ea9m:<br \/>\n Mol File: 124584-08-3.mol <\/p>\n<p> Nesiritide \u0111\u00e3 \u0111\u01b0\u1ee3c gi\u1edbi thi\u1ec7u \u1edf M\u1ef9 nh\u01b0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb t\u0129nh m\u1ea1ch m\u1edbi cho b\u1ec7nh nh\u00e2n Suy tim sung huy\u1ebft m\u1ea5t b\u00f9 c\u1ea5p t\u00ednh kh\u00f3 th\u1edf khi ngh\u1ec9 ng\u01a1i ho\u1eb7c v\u1edbi ho\u1ea1t \u0111\u1ed9ng t\u1ed1i thi\u1ec3u ng\u1ee9a. Nesiritide l\u00e0 d\u1ea1ng t\u00e1i t\u1ed5 h\u1ee3p \u0111\u1ea7u ti\u00ean \u1edf ng\u01b0\u1eddi c\u1ee7a peptit natri l\u1ee3i ti\u1ec3u lo\u1ea1i B c\u00f3 t\u00e1c d\u1ee5ng gi\u00e3n m\u1ea1ch m\u1ea1nh (c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 peptit l\u1ee3i ti\u1ec3u natri), m\u1ed9t peptit 32 axit amin c\u00f3 trong t\u1ef1 nhi\u00ean v\u1edbi c\u1ea5u tr\u00fac v\u00f2ng 17 axit amin li\u00ean k\u1ebft v\u1edbi disulfua. Nesiritide li\u00ean k\u1ebft v\u1edbi th\u1ee5 th\u1ec3 peptide b\u00e0i ni\u1ec7u Atype natri tr\u00ean b\u1ec1 m\u1eb7t c\u1ee7a t\u1ebf b\u00e0o n\u1ed9i m\u00f4 v\u00e0 c\u01a1 tr\u01a1n, k\u00edch th\u00edch s\u1ea3n xu\u1ea5t cGMP th\u00f4ng tin th\u1ee9 hai c\u00f3 t\u00e1c d\u1ee5ng trung gian ch\u1ee7 y\u1ebfu l\u00e0 gi\u00e3n t\u1ebf b\u00e0o c\u01a1 tr\u01a1n m\u1ea1ch m\u00e1u. N\u00f3 c\u0169ng t\u1ea1o \u0111i\u1ec1u ki\u1ec7n thu\u1eadn l\u1ee3i cho vi\u1ec7c lo\u1ea1i b\u1ecf natri v\u00e0 n\u01b0\u1edbc c\u1ee7a th\u1eadn v\u00e0 l\u00e0m gi\u1ea3m s\u1ef1 b\u00e0i ti\u1ebft c\u1ee7a m\u1ed9t s\u1ed1 hormone, ch\u1eb3ng h\u1ea1n nh\u01b0 adrenalin, angiotensin II, aldosterone v\u00e0 endothelin, g\u00e2y ra c\u00e1c t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i l\u00e2u d\u00e0i bao g\u1ed3m co th\u1eaft m\u1ea1ch m\u00e1u v\u00e0 t\u0103ng huy\u1ebft \u00e1p. Trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u1edbi b\u1ec7nh nh\u00e2n suy tim, nesidtide ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u l\u01b0\u1ee3ng l\u00e0m gi\u1ea3m \u00e1p l\u1ef1c n\u00eam mao m\u1ea1ch ph\u1ed5i, \u00e1p l\u1ef1c t\u00e2m nh\u0129 ph\u1ea3i v\u00e0 s\u1ee9c c\u1ea3n m\u1ea1ch h\u1ec7 th\u1ed1ng v\u00e0 t\u0103ng ch\u1ec9 s\u1ed1 tim m\u00e0 kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn nh\u1ecbp tim. T\u00e1c d\u1ee5ng ngo\u1ea1i \u00fd ch\u00ednh \u0111\u01b0\u1ee3c quan s\u00e1t l\u00e0 h\u1ea1 huy\u1ebft \u00e1p ph\u1ee5 thu\u1ed9c v\u00e0o li\u1ec1u l\u01b0\u1ee3ng. Trong m\u1ed9t th\u1eed nghi\u1ec7m so s\u00e1nh giai \u0111o\u1ea1n III, nesiritide \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y l\u00e0 v\u01b0\u1ee3t tr\u1ed9i h\u01a1n iv. nitroglycerine v\u1ec1 t\u00e1c d\u1ee5ng huy\u1ebft \u0111\u1ed9ng c\u0169ng nh\u01b0 d\u1ec5 s\u1eed d\u1ee5ng h\u01a1n v\u00e0 dung n\u1ea1p t\u1ed1t h\u01a1n. Nesiritide \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i b\u1eb1ng c\u00e1ch ph\u00e2n c\u1eaft protein b\u1edfi enzym endopeptidase trung t\u00ednh NEP24.11 v\u00e0 b\u1eb1ng c\u00e1ch li\u00ean k\u1ebft v\u1edbi th\u1ee5 th\u1ec3 peptide natri l\u1ee3i ti\u1ec3u lo\u1ea1i C, sau \u0111\u00f3 l\u00e0 qu\u00e1 tr\u00ecnh n\u1ed9i b\u00e0o v\u00e0 th\u1ee7y ph\u00e2n lysosome n\u1ed9i b\u00e0o. V\u00ec n\u00f3 c\u00f3 th\u1eddi gian b\u00e1n h\u1ee7y ng\u1eafn (18 ph\u00fat), nesiritide \u0111\u01b0\u1ee3c d\u00f9ng d\u01b0\u1edbi d\u1ea1ng truy\u1ec1n li\u1ec1u 21\u03bcg \/ kg, sau \u0111\u00f3 l\u00e0 truy\u1ec1n duy tr\u00ec li\u00ean t\u1ee5c \u1edf 0,011\u03bcg \/ kg \/ ph\u00fat th\u01b0\u1eddng trong 24-48 gi\u1edd. <\/p>\n<p> <strong>Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3 T\u00ednh ch\u1ea5t h\u00f3a h\u1ecdc<\/strong><br \/>\n BNP-32 (HUMAN) T\u00ednh ch\u1ea5t h\u00f3a h\u1ecdc<br \/>\n t\u1ef7 tr\u1ecdng 1,52 \u00b1 0,1 g \/ cm3 (D\u1ef1 \u0111o\u00e1n)<br \/>\n RTECS EE1534000<br \/>\n nhi\u1ec7t \u0111\u1ed9 l\u01b0u tr\u1eef. \u221220 \u00b0 C<br \/>\n d\u1ea1ng b\u1ed9t<br \/>\n T\u00ednh tan trong n\u01b0\u1edbc H\u00f2a tan trong n\u01b0\u1edbc \u1edf 1mg \/ ml<br \/>\n CAS DataBase Reference 124584-08-3 <\/p>\n<p> <strong>Ch\u1ee9c n\u0103ng v\u00e0 \u1ee9ng d\u1ee5ng c\u1ee7a Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3<\/strong><br \/>\n \u0110i\u1ec1u tr\u1ecb suy tim sung huy\u1ebft (ch\u1ea5t \u0111\u1ed1i kh\u00e1ng h\u1ec7 th\u1ed1ng renin-angiotensin).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>T\u00ean s\u1ea3n ph\u1ea9m: Nesiritide \/ BNP-32 (HUMAN)<br \/>\n CAS: 124584-08-3<br \/>\n MF: C143H244N50O42S4<br \/>\n MW: 3464.04<br \/>\n EINECS: 1312995-182-4<br \/>\n Danh m\u1ee5c s\u1ea3n ph\u1ea9m: &lt; &amp;&gt; Mol T\u1ec7p: 124584-08-3.mol<\/p>\n","protected":false},"featured_media":2304,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[508],"product_tag":[1144],"class_list":{"0":"post-8584","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-he-thong-tim-mach-peptide","7":"product_tag-nesiritide-bnp-32-human-cas-124584-08-3-brain-natriuretic-peptide-for-heart-failure-vi","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/product\/8584","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/comments?post=8584"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/media\/2304"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/media?parent=8584"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/product_brand?post=8584"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/product_cat?post=8584"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/product_tag?post=8584"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}