{"id":352,"count":10,"description":"Hi\u1ec7n nay, thu\u1ed1c peptide \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong c\u00e1c l\u0129nh v\u1ef1c \u0111i\u1ec1u tr\u1ecb kh\u00e1c nhau, ch\u1eb3ng h\u1ea1n nh\u01b0 b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng, d\u1ecb \u1ee9ng, ch\u1ed1ng nhi\u1ec5m tr\u00f9ng, b\u00e9o ph\u00ec, ch\u1ea9n \u0111o\u00e1n, ung th\u01b0, vi\u00eam kh\u1edbp v\u00e0 c\u00e1c b\u1ec7nh tim m\u1ea1ch. So v\u1edbi thu\u1ed1c h\u00f3a h\u1ecdc ph\u00e2n t\u1eed nh\u1ecf truy\u1ec1n th\u1ed1ng, thu\u1ed1c peptid ho\u1ea1t t\u00ednh c\u00f3 nh\u1eefng \u01b0u \u0111i\u1ec3m ri\u00eang bi\u1ec7t nh\u01b0: tr\u1ecdng l\u01b0\u1ee3ng ph\u00e2n t\u1eed nh\u1ecf, c\u1ea5u tr\u00fac \u0111\u01a1n gi\u1ea3n v\u00e0 kh\u00f4ng c\u00f3 t\u00ednh sinh mi\u1ec5n d\u1ecbch; c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng r\u00f5 r\u00e0ng v\u00e0 \u00edt t\u00e1c d\u1ee5ng ph\u1ee5; \u0111\u1ed9 tinh khi\u1ebft t\u1ed5ng h\u1ee3p cao v\u00e0 t\u1ed5ng h\u1ee3p d\u1ec5 d\u00e0ng. Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, t\u1ed1c \u0111\u1ed9 t\u0103ng tr\u01b0\u1edfng t\u1ed5ng h\u1ee3p c\u1ee7a th\u1ecb tr\u01b0\u1eddng thu\u1ed1c peptide to\u00e0n c\u1ea7u l\u00e0 tr\u00ean 12% v\u00e0 quy m\u00f4 th\u1ecb tr\u01b0\u1eddng \u0111\u1ea1t g\u1ea7n 20 t\u1ef7 USD, cao h\u01a1n so v\u1edbi th\u1ecb tr\u01b0\u1eddng thu\u1ed1c n\u00f3i chung. Theo T\u1ed5 ch\u1ee9c Nghi\u00ean c\u1ee9u Th\u1ecb tr\u01b0\u1eddng Minh b\u1ea1ch, th\u1ecb tr\u01b0\u1eddng thu\u1ed1c peptide to\u00e0n c\u1ea7u d\u1ef1 ki\u1ebfn \u200b\u200b\u0111\u1ea1t 23,7 t\u1ef7 USD v\u00e0o n\u0103m 2020, tr\u1edf th\u00e0nh \u0111\u1ecbnh h\u01b0\u1edbng quan tr\u1ecdng cho ho\u1ea1t \u0111\u1ed9ng R&D thu\u1ed1c m\u1edbi c\u1ee7a c\u00e1c c\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m n\u01b0\u1edbc ngo\u00e0i. C\u00e1c \u0111\u1ea1i gia d\u01b0\u1ee3c ph\u1ea9m Pfizer, Merck, Roche, Eli Lilly, Novartis, Sanofi, Bayer v\u00e0 c\u00e1c c\u00f4ng ty d\u01b0\u1ee3c ph\u1ea9m \u0111a qu\u1ed1c gia l\u1edbn kh\u00e1c \u0111\u00e3 \u0111\u1ea7u t\u01b0 v\u00e0o nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n thu\u1ed1c peptide trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y. Hi\u1ec7n t\u1ea1i, c\u00e1c lo\u1ea1i thu\u1ed1c peptide \u0111\u1ea1i di\u1ec7n to\u00e0n c\u1ea7u l\u00e0 liraglutide, dulaglutide, glatiramer acetate, leuprorelin acetate, octreotide acetate, goserelin v\u00e0 eserin. goserelin v\u00e0 exenatide, v.v.\r\n\r\nHi\u1ec7n nay c\u00e1c peptit ch\u1ed1ng b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng bao g\u1ed3m Exenatide Acetate CAS 141732-76-5<\/a>, GLP-1 (7-37) CAS 106612-94-6<\/a>, Glucagon CAS 16941-32-5<\/a>, Dulaglutide CAS 923950-08-7<\/a>, Albiglutide CAS 782500-75 -8<\/a>, Liraglutide CAS 204656-20-2<\/a>, Lisiraglide CAS 320367-13-3<\/a>, Pramlintide Acetate CAS 196078-30-5<\/a>, Tirzepatide CAS 2023788-19-2<\/a>, Semaglutide Cas 910463-68-2<\/a>.\r\n\r\n\u0110\u00e1i th\u00e1o \u0111\u01b0\u1eddng l\u00e0 b\u1ec7nh m\u00e3n t\u00ednh, c\u00f3 nhi\u1ec1u y\u1ebfu t\u1ed1 nguy c\u01a1, c\u01a1 ch\u1ebf b\u1ec7nh sinh ph\u1ee9c t\u1ea1p v\u00e0 di\u1ec5n bi\u1ebfn su\u1ed1t \u0111\u1eddi. B\u1ec7nh nh\u00e2n t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft th\u01b0\u1eddng k\u00e8m theo t\u0103ng huy\u1ebft \u00e1p, t\u0103ng lipid m\u00e1u v\u00e0 kh\u00e1ng insulin. T\u0103ng huy\u1ebft \u00e1p v\u00e0 t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft th\u01b0\u1eddng x\u1ea3y ra c\u00f9ng nhau, trong khi kho\u1ea3ng 60% b\u1ec7nh nh\u00e2n t\u0103ng huy\u1ebft \u00e1p c\u00f3 th\u1ec3 b\u1ecb t\u0103ng \u0111\u01b0\u1eddng huy\u1ebft ho\u1eb7c dung n\u1ea1p glucose b\u1ea5t th\u01b0\u1eddng.\r\n\r\nTi\u1ec1n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng ch\u1ee7 y\u1ebfu d\u1ef1a v\u00e0o c\u00e1c bi\u1ec7n ph\u00e1p can thi\u1ec7p l\u1ed1i s\u1ed1ng, v\u00e0 giai \u0111o\u1ea1n \u0111\u1ea7u l\u00e0 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft b\u1eb1ng thu\u1ed1c u\u1ed1ng h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft \u0111\u1ea1i di\u1ec7n l\u00e0 metformin. Khi hemoglobin glycosyl h\u00f3a c\u1ee7a b\u1ec7nh nh\u00e2n v\u1eabn v\u01b0\u1ee3t qu\u00e1 7 sau khi d\u00f9ng li\u1ec1u cao thu\u1ed1c h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft, th\u00ec c\u1ea7n ph\u1ea3i \u0111i\u1ec1u tr\u1ecb b\u1eb1ng insulin. Insulin l\u00e0 ph\u1ea7n quan tr\u1ecdng nh\u1ea5t c\u1ee7a \u0111i\u1ec1u tr\u1ecb h\u00e0ng th\u1ee9 ba v\u00e0 th\u1ee9 t\u01b0 v\u00e0 l\u00e0 tuy\u1ebfn b\u1ea3o v\u1ec7 cu\u1ed1i c\u00f9ng cho b\u1ec7nh nh\u00e2n \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng. Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, thu\u1ed1c \u1ee9c ch\u1ebf DPP-4, thu\u1ed1c ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1 v\u00e0 thu\u1ed1c \u1ee9c ch\u1ebf SGLT2 \u0111\u00e3 ph\u00e1t tri\u1ec3n v\u1edbi t\u1ed1c \u0111\u1ed9 \u0111\u00e1ng k\u1ec3.\r\n\r\nV\u00e0o nh\u1eefng n\u0103m 1980, peptide-1 gi\u1ed1ng glucagon (GLP-1) \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n c\u00f3 c\u00e1c t\u00e1c d\u1ee5ng sinh l\u00fd nh\u01b0 k\u00edch th\u00edch t\u1ed5ng h\u1ee3p v\u00e0 b\u00e0i ti\u1ebft insulin ph\u1ee5 thu\u1ed9c v\u00e0o glucose, \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh apoptosis c\u1ee7a t\u1ebf b\u00e0o B \u1edf \u0111\u1ea3o nh\u1ecf v\u00e0 \u1ee9c ch\u1ebf b\u00e0i ti\u1ebft glucagon. v\u00e0 polypeptide ti\u1ebft ra proinsulin ph\u1ee5 thu\u1ed9c glucose (GIP) \u0111\u01b0\u1ee3c ru\u1ed9t ti\u1ebft ra su\u1ed1t c\u1ea3 ng\u00e0y v\u00e0 m\u1ee9c \u0111\u1ed9 c\u1ee7a ch\u00fang t\u0103ng l\u00ean sau b\u1eefa \u0103n. GLP-1 v\u00e0 GIP l\u00e0m t\u0103ng t\u1ed5ng h\u1ee3p v\u00e0 ph\u00f3ng th\u00edch insulin khi n\u1ed3ng \u0111\u1ed9 glucose trong m\u00e1u \u1edf m\u1ee9c b\u00ecnh th\u01b0\u1eddng ho\u1eb7c t\u0103ng cao. Ho\u1ea1t \u0111\u1ed9ng c\u1ee7a GLP-1 v\u00e0 GIP b\u1ecb \u1ee9c ch\u1ebf b\u1edfi dipeptidyl peptidase DPP-IV (DPP-IV), ch\u1ea5t n\u00e0y nhanh ch\u00f3ng th\u1ee7y ph\u00e2n enteroglucagon v\u00e0 l\u00e0m b\u1ea5t ho\u1ea1t n\u00f3. S\u1ef1 \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a DPP-IV l\u00e0m gi\u1ea3m s\u1ef1 tho\u00e1i h\u00f3a c\u1ee7a enteroglucagon, l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 GLP-1 v\u00e0 GIP ho\u1ea1t \u0111\u1ed9ng trong huy\u1ebft t\u01b0\u01a1ng v\u00e0 th\u00fac \u0111\u1ea9y gi\u1ea3i ph\u00f3ng insulin, do \u0111\u00f3 l\u00e0m gi\u1ea3m m\u1ee9c \u0111\u01b0\u1eddng huy\u1ebft. Do \u0111\u00f3, c\u00e1c lo\u1ea1i thu\u1ed1c peptide d\u1ef1a tr\u00ean s\u1ef1 \u1ee9c ch\u1ebf DPP-IV c\u0169ng l\u00e0 \u0111i\u1ec3m n\u00f3ng \u0111\u1ec3 ph\u00e1t tri\u1ec3n, nh\u01b0ng nghi\u00ean c\u1ee9u hi\u1ec7n t\u1ea1i v\u1eabn \u0111ang t\u1eadp trung v\u00e0o vi\u1ec7c ph\u00e1t tri\u1ec3n v\u00e0 s\u1eed d\u1ee5ng c\u00e1c peptide ch\u1ee9c n\u0103ng li\u00ean quan, v\u00e0 ch\u01b0a c\u00f3 lo\u1ea1i thu\u1ed1c peptide li\u00ean quan n\u00e0o \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o tr\u00ean th\u1ecb tr\u01b0\u1eddng. H\u1ea7u h\u1ebft c\u00e1c lo\u1ea1i thu\u1ed1c peptide \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t \u0111\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft \u1edf b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng l\u00e0 ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1, v\u00e0 c\u00f3 8 ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1 c\u00f3 s\u1eb5n tr\u00ean to\u00e0n th\u1ebf gi\u1edbi, \u0111\u00f3 l\u00e0 somalutide, exenatide, liraglutide, abilify, dulaglutide, lisnatide v\u00e0 benalutide. Li\u00ean quan \u0111\u1ebfn somalutide, vi\u1ec7c gi\u1ea3m glucose v\u00e0 gi\u1ea3m c\u00e2n \u1edf b\u1ec7nh nh\u00e2n ti\u1ec3u \u0111\u01b0\u1eddng lo\u1ea1i 2 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1ch ti\u00eam somalutide m\u1ed9t l\u1ea7n m\u1ed7i tu\u1ea7n t\u1ed1t h\u01a1n \u0111\u00e1ng k\u1ec3 so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c, selegiline, glargine insulin U100 v\u00e0 exenatide ph\u00f3ng th\u00edch k\u00e9o d\u00e0i. V\u00e0 c\u00f4ng th\u1ee9c h\u00e0ng tu\u1ea7n dulaglutide, liraglutide, somalutide v\u00e0 exenatide l\u00e0 nh\u1eefng c\u00f4ng th\u1ee9c c\u00f3 t\u00e1c d\u1ee5ng l\u00e2u d\u00e0i, c\u00f3 th\u1ec3 duy tr\u00ec trong m\u1ed9t tu\u1ea7n. Tuy nhi\u00ean, c\u00f3 m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ngo\u1ea1i \u00fd c\u1ee7a thu\u1ed1c ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1, nh\u00ecn chung kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn vi\u1ec7c \u0111i\u1ec1u tr\u1ecb, ch\u1eb3ng h\u1ea1n nh\u01b0 exelutide v\u00e0 liraglutide l\u00e0m t\u0103ng nh\u1ecbp tim nh\u1eb9.","link":"https:\/\/puyapeptide.net\/vi\/product-category\/peptide-tieu-duong\/","name":"Peptide ti\u1ec3u \u0111\u01b0\u1eddng","slug":"peptide-tieu-duong","taxonomy":"product_cat","parent":0,"meta":[],"menu_order":0,"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/product_cat\/352","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/product_cat"}],"about":[{"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/taxonomies\/product_cat"}],"wp:post_type":[{"href":"https:\/\/puyapeptide.net\/vi\/wp-json\/wp\/v2\/product?product_cat=352"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}